Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.
Diabetol Metab Syndr. 2010 Apr 20;2:24. doi: 10.1186/1758-5996-2-24.
Elevated serum uric acid levels (SUA) have been associated with an increased risk of cardiovascular diseases and the metabolic syndrome (MetS) and are often reported to be higher in females than in males. The aim of this report is to determine the prevalence and clinical correlates of hyperuricaemia and also to evaluate associations with the MetS in people with type 2 diabetes mellitus (DM).
This was a cross-sectional study conducted in people with type 2 DM in Lagos, Nigeria. Hyperuricaemia was defined by cut-off values of > 7 mg/dl for men and > 6 mg/dl for women. The diagnosis of MetS was made using the new definition by the American Heart Association and other related bodies. Clinical and biochemical parameters were compared between subjects with hyperuricaemia and normouricaemia. Statistical analysis included usage of Student's t test, Pearson correlation coefficients, multivariate regression analysis and chi square.
601 patients with type 2 DM aged between 34-91 years were recruited for the study. The prevalence rates of hyperuricaemia and the MetS were 25% and 60% respectively. The frequency of occurrence of hyperuricaemia was comparable in both genders (59% vs 41%, p = 0.3). Although, the prevalence of the MetS in subjects with hyperuricaemia and normouricaemia was comparable (61 vs 56%, p = 0.1), a higher proportion of hyperuricaemic subjects had 3 or more components of the Mets compared with normouricaemic subjects. Possible predictors of hyperuricaemia include central obesity, smoking and elevated serum triglycerides (TG). SUA levels were found to be positively and significantly associated with serum TG (r = 0.2, p = 0.0001) and total cholesterol (r = 13, p = 0.001).
The prevalence of hyperuricaemia in subjects with type 2 DM is comparable in both genders and possible predictors of hyperuricaemia are potentially modifiable. SUA is positively and significantly associated with serum TG and total cholesterol.
血清尿酸水平升高（SUA）与心血管疾病和代谢综合征（MetS）的风险增加有关，且女性的 SUA 水平通常高于男性。本报告的目的是确定高尿酸血症的患病率和临床相关性，并评估其与 2 型糖尿病（DM）患者 MetS 的关系。
这是一项在尼日利亚拉各斯进行的 2 型 DM 患者的横断面研究。高尿酸血症的定义为男性> 7mg/dl，女性> 6mg/dl。MetS 的诊断采用美国心脏协会和其他相关机构的新定义。比较高尿酸血症和正常尿酸血症患者的临床和生化参数。统计分析包括使用学生 t 检验、Pearson 相关系数、多元回归分析和卡方检验。
共招募了 601 名年龄在 34-91 岁之间的 2 型 DM 患者进行研究。高尿酸血症和 MetS 的患病率分别为 25%和 60%。两种性别高尿酸血症的发生率相似（59% vs 41%，p = 0.3）。尽管高尿酸血症和正常尿酸血症患者的 MetS 患病率相似（61% vs 56%，p = 0.1），但高尿酸血症患者中有更多的人有 3 个或更多 MetS 成分。高尿酸血症的可能预测因素包括中心性肥胖、吸烟和血清甘油三酯（TG）升高。SUA 水平与血清 TG（r = 0.2，p = 0.0001）和总胆固醇（r = 0.13，p = 0.001）呈正相关且显著相关。
2 型 DM 患者高尿酸血症的患病率在两性中相似，高尿酸血症的可能预测因素是潜在可改变的。SUA 与血清 TG 和总胆固醇呈正相关且显著相关。
