Section of Physical Education and Sports, University of Zaragoza, Zaragoza, Spain.
Scand J Med Sci Sports. 2011 Apr;21(2):244-9. doi: 10.1111/j.1600-0838.2009.01042.x.
Numerous studies have observed cardiac biomarker release with prolonged exercise. Despite this, we are unsure as to the constituent aspects of any given exercise bout that may be important in promoting cardiac biomarker release. This study examined the influence of exercise duration and intensity on the appearance of cardiac biomarkers. Twenty-one subjects ran for 45, 90 and 180 min at 85% and 95% of their individual anaerobic threshold on six different days randomized. Cardiac troponin I (cTnI) and N-terminal pro-brain natiuretic peptide (NT-proBNP) were assayed from blood samples collected before, 30 min and 3 h post-exercise. NT-proBNP was elevated after all exercise trials (range before: 21-32; range post: 38-67 ng/L). Peak post-exercise concentrations of NT-proBNP were associated with exercise duration (P=0.049), but not exercise intensity (P=0.451). cTnI was elevated after all exercise trials (range before: 0.007-0.011; range post: 0.008-0.021 μg/L). Peak post-exercise concentrations of cTnI were associated with exercise duration (P=0.003) and intensity (P=0.037). Data suggest that while both cTnI and NT-proBNP increased after all exercise trials, the mediating effect of duration influenced both NT-proBNP and cTnI while intensity influenced only cTnI.
许多研究观察到长时间运动后心脏生物标志物的释放。尽管如此，我们仍不确定任何给定运动过程中的组成部分可能对促进心脏生物标志物释放很重要。本研究检查了运动持续时间和强度对心脏生物标志物出现的影响。21 名受试者在六天的随机时间内以 85%和 95%的个人无氧阈值分别进行 45、90 和 180 分钟的跑步。在运动前、30 分钟和 3 小时从采集的血液样本中测定肌钙蛋白 I (cTnI)和 N 末端脑利钠肽前体 (NT-proBNP)。所有运动试验后 NT-proBNP 升高（运动前范围：21-32；运动后范围：38-67ng/L）。NT-proBNP 的峰值运动后浓度与运动持续时间相关（P=0.049），但与运动强度无关（P=0.451）。所有运动试验后 cTnI 均升高（运动前范围：0.007-0.011；运动后范围：0.008-0.021μg/L）。cTnI 的峰值运动后浓度与运动持续时间（P=0.003）和强度（P=0.037）相关。数据表明，虽然所有运动试验后 cTnI 和 NT-proBNP 均升高，但持续时间的介导作用影响了 NT-proBNP 和 cTnI，而强度仅影响 cTnI。
