Frassl W, Kowoll R, Katz N, Speth M, Stangl A, Brechtel L, Joscht B, Boldt L H, Meier-Buttermilch R, Schlemmer M, Roecker L, Gunga H C
Center for Space Medicine Berlin (ZWMB), Department of Physiology, Charité - University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
Clin Lab. 2008;54(3-4):81-7.
Transient cardiac ventricular dysfunction or sudden cardiac deaths have been reported for male athletes participating in marathon racing. Less is known about the myocardial response in females. We examined natriuretic peptides and cardiac troponins in female athletes after a marathon.
At the 31st real,- Berlin Marathon plasma levels of NT-pro-BNP, BNP, cTnI and cTnT were measured in 15 women (age 35+/-6 years; finishing times between 3:22 h and 5:21 h) at four different time points (before, immediately after, day one and day three).
An increase in [NT-pro-BNP] was observed immediately after the marathon (median [NT-pro-BNP] before: 39.6 pg ml(-1), after: 138.6 pg ml(-1), p=0.003) with a further increase on day one. [BNP] did not increase immediately after the marathon but increased on day one (median [BNP] before: 15 pg ml(-1), day one: 27.35 pg ml(-1), p=0.006). On day three, [NT-pro-BNP] and [BNP] returned to initial values. [cTnI] was under the detection limit prior to the marathon in all runners. [cTnT] was under the detection limit before the marathon except in one runner who presented a concentration of 0.03 ng ml(-1). Cardiac troponins (median [cTnl] after: 0.098 ng ml(-1), p=0.028; median [cTnT] after: 0.032 ng ml(-1), p=0.012) increased immediately after the marathon and returned to initial values on day one [cTnT] and three [cTnI].
Parameters representing cardiac stress increased in females after a marathon. Different kinetics of natriuretic peptides BNP and NT-pro-BNP post-marathon could be due to their different half-lives and dependence on renal function. The increase of cTnI and cTnT may result from minor myocardial lesions.
有报道称参加马拉松比赛的男性运动员会出现短暂性心室功能障碍或心源性猝死。而关于女性运动员心肌反应的了解较少。我们检测了马拉松赛后女性运动员的利钠肽和心肌肌钙蛋白。
在第31届柏林马拉松比赛中，对15名女性（年龄35±6岁；完赛时间在3:22小时至5:21小时之间）在四个不同时间点（赛前、赛后即刻、第一天和第三天）测量了NT-pro-BNP、BNP、cTnI和cTnT的血浆水平。
马拉松赛后即刻观察到[NT-pro-BNP]升高（赛前[NT-pro-BNP]中位数：39.6 pg/ml，赛后：138.6 pg/ml，p = 0.003），第一天进一步升高。[BNP]在马拉松赛后即刻未升高，但在第一天升高（赛前[BNP]中位数：15 pg/ml，第一天：27.35 pg/ml，p = 0.006）。第三天，[NT-pro-BNP]和[BNP]恢复到初始值。所有参赛者在马拉松赛前[cTnI]均低于检测限。除一名浓度为0.03 ng/ml的参赛者外，马拉松赛前[cTnT]均低于检测限。马拉松赛后即刻心肌肌钙蛋白升高（赛后[cTnl]中位数：0.098 ng/ml，p = 0.028；赛后[cTnT]中位数：0.032 ng/ml，p = 0.012），并在第一天[cTnT]和第三天[cTnI]恢复到初始值。
马拉松赛后女性中代表心脏应激的参数升高。马拉松赛后利钠肽BNP和NT-pro-BNP的不同动力学可能归因于它们不同的半衰期以及对肾功能的依赖性。cTnI和cTnT的升高可能源于轻微的心肌损伤。
