Swick Brian L, Gordon Jennifer R S
Department of Dermatology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
J Cutan Pathol. 2010 Dec;37(12):1245-50. doi: 10.1111/j.1600-0560.2009.01471.x.
Cutaneous metastases from transitional cell carcinoma of the bladder are rare and most often associated with a deeply invasive primary tumor. This case report describes a 69-year-old male with previously resected superficially invasive primary transitional cell carcinoma of the bladder who presented with distant cutaneous and central nervous system metastases associated with recurrent bladder cancer. In addition, this case highlights the differential diagnosis of metastatic carcinomas that display a CK7/CK20 positive immunophenotype including transitional cell carcinoma, pancreatic carcinoma, cholangiocarcinoma and rare gastric carcinomas.
膀胱移行细胞癌的皮肤转移罕见,且大多与深部浸润性原发性肿瘤相关。本病例报告描述了一名69岁男性,其既往切除过浅表浸润性原发性膀胱移行细胞癌,现出现与复发性膀胱癌相关的远处皮肤和中枢神经系统转移。此外,本病例突出了对表现为CK7/CK20阳性免疫表型的转移性癌的鉴别诊断,包括移行细胞癌、胰腺癌、胆管癌和罕见的胃癌。