Mareedu Ravi K, Abdalrahman Ihab B, Dharmashankar Kodlipet C, Granada Juan F, Chyou Po-Huang, Sharma Param P, Smith Peter N, Hayes John J, Greenlee Robert T, Vidaillet Humberto
Cardiac Electrophysiology, Department of Cardiology, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA.
Clin Med Res. 2010 Mar;8(1):1-6. doi: 10.3121/cmr.2009.851. Epub 2009 Nov 17.
Determine and compare the prevalence of known risk factors for cardiovascular disease among unselected individuals presenting with their first ever episode of atrial flutter (AFL) and atrial fibrillation (AF).
We evaluated 11 pre-selected clinical variables including age, sex, smoking history and other potential cardiac risk factors. Using the resources of the Marshfield Epidemiologic Study Area, a population-based database, all newly diagnosed cases of either AFL or AF in the region during a 4-year period were identified.
Among the 472 incident cases, 76 (16.1%) had AFL and 396 (83.9%) had AF. Compared to those with AF, subjects with AFL were more likely to have had a history of chronic obstructive pulmonary disease (25% vs. 12%, P = 0.006), heart failure (28% vs. 17%, P = 0.05), and smoking (49% vs. 37%, P = 0.06). Hypertension, on the other hand, was more common among individuals with AF (63% vs. 47%, P = 0.01).
This study represents the first report to evaluate potential differences in the conditions associated with the development of AFL versus AF. Research into the mechanisms of atrial arrhythmogenesis may lead to improved preventive and therapeutic interventions.
确定并比较首次发生心房扑动（AFL）和心房颤动（AF）的未经过筛选的个体中已知心血管疾病风险因素的患病率。
我们评估了11个预先选定的临床变量，包括年龄、性别、吸烟史和其他潜在的心脏风险因素。利用基于人群的数据库马什菲尔德流行病学研究区域的资源，确定了该地区4年期间所有新诊断的AFL或AF病例。
在472例新发病例中，76例（16.1%）为AFL，396例（83.9%）为AF。与AF患者相比，AFL患者更有可能有慢性阻塞性肺疾病史（25%对12%，P = 0.006）、心力衰竭史（28%对17%，P = 0.05）和吸烟史（49%对37%，P = 0.06）。另一方面，高血压在AF患者中更为常见（63%对47%，P = 0.01）。
本研究是评估与AFL和AF发生相关情况潜在差异的首份报告。对心房心律失常发生机制的研究可能会带来更好的预防和治疗干预措施。
