海德堡视网膜断层扫描仪检测早期青光眼视野损失的能力。

Ability of the heidelberg retina tomograph to detect early glaucomatous visual field loss.

机构信息

*Departments of Ophthalmology and daggerMechanical Engineering, University of British Columbia, Vancouver, B.C., double dagger;Medical Engineering Group, Faculty of Engineering and Applied Science, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

出版信息

J Glaucoma. 1995 Aug;4(4):242-7.

PMID:19920681

Abstract

PURPOSE

The Heidleberg Retina Tomograph provides rapid, reproducible measurements of optic disc topography as well as calculations of disc parameters. We used a stepwise discriminant analysis to determine which parameters were most useful in detecting individuals with early glaucomatous visual field loss.

METHODS

We studied one eye in each of 45 normal individuals and one eye in each of 46 individuals with early glaucomatous visual field loss. The appearance of the optic disc was not used for classification purposes so as not to bias the diagnostic determination obtained by the instrument. The data were analyzed using the reference plane of the software version 1.10 and using a method incorporating the height of the papillomacular bundle as reference level with and without age correction.

RESULTS

We obtained an 89% sensitivity and 78% specificity for the detection of early visual field loss using the standard reference level. The jackknife classification revealed lower sensitivity of 87% and an unchanged specificity of 78%. With the method incorporating the height of the papillomacular bundle as reference level, the sensitivity was 87% and the specificity was 84% for detecting early visual field loss. The jackknife classification revealed a sensitivity of 87% and a specificity of 82%. With the age correction, the sensitivity was 87%, specificity 84% with regular and jackknife classification. With the standard reference level, the important parameters were the third moment and the maximum depth, with the papillomacular bundle reference level volume above reference level added as important, and with age correction, height variation in contour replaced maximum depth in the analysis.

CONCLUSION

Three significant shape parameters of the optic disc can be used to detect early glaucomatous visual field loss.

摘要

目的

海德堡视网膜断层扫描仪（Heidleberg Retina Tomograph）可快速、可重复地测量视盘地形，并计算视盘参数。我们使用逐步判别分析来确定哪些参数最有助于检测早期青光眼视野丧失的个体。

方法

我们研究了 45 名正常个体的每只眼和 46 名早期青光眼视野丧失个体的每只眼。为了避免仪器获得的诊断结果受到视盘外观分类的影响，我们并未对视盘外观进行分类。我们使用软件版本 1.10 的参考平面和包含神经纤维束高度的参考水平（带或不带年龄校正）对数据进行了分析。

结果

使用标准参考水平，我们获得了 89%的敏感性和 78%的特异性，用于检测早期视野丧失。刀切法分类显示敏感性为 87%，特异性为 78%，无变化。使用包含神经纤维束高度的参考水平的方法，敏感性为 87%，特异性为 84%，用于检测早期视野丧失。刀切法分类显示敏感性为 87%，特异性为 82%。使用年龄校正时，常规和刀切法分类的敏感性均为 87%，特异性均为 84%。使用标准参考水平时，重要的参数是第三阶矩和最大深度，使用神经纤维束参考水平体积增加作为重要参数，使用年龄校正时，轮廓高度变化取代了分析中的最大深度。