Eryildirim Bilal, Kuyumcuoğlu Uğur, Tarhan Fatih, Faydaci Gökhan, Uruç Fatih
Lutfi Kirdar Training and Research Hospital 1, Urology Clinics, Istanbul, Turkey.
Urol Int. 2009;82(3):276-9. doi: 10.1159/000209357. Epub 2009 May 11.
In this prospective and randomized study, we aimed to compare the efficacy of a eutectic mixture of local anesthetics (EMLA) cream, diclofenac sodium (DS) and EMLA in combination with DS (EMLA+DS) for pain management during extracorporeal shock wave lithotripsy (ESWL).
120 patients who had undergone ESWL for renal stones were included in the study. The patients were randomized into three groups: the first group was treated with a eutectic mixture of local anesthetics cream (EMLA), while intramuscular DS was applied to the second group and EMLA+DS was applied to the third group. Pain during ESWL was assessed with the 10-score linear and visual analogue pain scale and was compared between groups.
Mean age was 44.4 +/- 1.9 years. There was no statistically significant difference between groups regarding patients' mean age, weight, stone size, shock waves, duration of ESWL and energy level values (p > 0.05). The mean pain score during ESWL was 3.90 +/- 0.16 in the EMLA group, 3.28 +/- 0.18 in the DS group and 3.05 +/- 0.18 in EMLA+DS group (p = 0023).
DS appears to be more efficient than EMLA in reducing pain during ESWL. Using EMLA+DS has no superiority in relieving pain compared to DS-only treatment.
在这项前瞻性随机研究中,我们旨在比较复方利多卡因(EMLA)乳膏、双氯芬酸钠(DS)以及EMLA与DS联合使用(EMLA+DS)在体外冲击波碎石术(ESWL)期间用于疼痛管理的疗效。
120例接受ESWL治疗肾结石的患者纳入本研究。患者被随机分为三组:第一组用复方利多卡因乳膏(EMLA)治疗,第二组肌肉注射DS,第三组应用EMLA+DS。ESWL期间的疼痛采用10分线性视觉模拟疼痛量表进行评估,并在组间进行比较。
平均年龄为44.4±1.9岁。在患者的平均年龄、体重、结石大小、冲击波、ESWL持续时间和能量水平值方面,组间无统计学显著差异(p>0.05)。EMLA组ESWL期间的平均疼痛评分为3.90±0.16,DS组为3.28±0.18,EMLA+DS组为3.05±0.18(p=0.023)。
在ESWL期间减轻疼痛方面,DS似乎比EMLA更有效。与仅使用DS治疗相比,使用EMLA+DS在缓解疼痛方面没有优势。