蔓越莓汁预防儿童复发性尿路感染：一项随机对照试验
Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children.
作者信息
Ferrara Pietro, Romaniello Luciana, Vitelli Ottavio, Gatto Antonio, Serva Martina, Cataldi Luigi
机构信息
Department of Pediatrics, Catholic University, A. Gemelli Hospital, Rome, Italy.
出版信息
Scand J Urol Nephrol. 2009;43(5):369-72. doi: 10.3109/00365590902936698.
OBJECTIVE
This study compares the effects of daily cranberry juice to those of Lactobacillus in children with recurrent urinary tract infections (UTIs).
MATERIAL AND METHODS
Eighty-four girls aged between 3 and 14 years were randomized to cranberry, Lactobacillus or control in three treatment arms: G1, cranberry juice 50 ml daily (n=28); G2, 100 ml of Lactobacillus GG drink on 5 days a month (n=27); and G3, controls (n=29). The study lasted for 6 months.
RESULTS
Only four subjects withdrew: 1/28 (3.5%) from G1, 1/27 (3.7%) from G2 and 2/29 (6.8%) from G3, because of poor compliance to the established protocol. There were 34 episodes of UTIs in this cohort: 5/27 (18.5%) in G1, 11/26 (42.3%) in G2 and 18/27 (48.1%) in the G3, with at least one episode of infection (p<0.05).
CONCLUSION
These data suggest that daily consumption of concentrated cranberry juice can significantly prevent the recurrence of symptomatic UTIs in children.
目的
本研究比较每日饮用蔓越莓汁与服用乳酸菌对复发性尿路感染（UTI）患儿的影响。
材料与方法
84名3至14岁的女孩被随机分为蔓越莓组、乳酸菌组或对照组，分为三个治疗组：G1组，每日饮用50毫升蔓越莓汁（n = 28）；G2组，每月5天每天饮用100毫升含鼠李糖乳杆菌GG的饮品（n = 27）；G3组为对照组（n = 29）。研究持续6个月。
结果
仅4名受试者退出：G1组1/28（3.5%），G2组1/27（3.7%），G3组2/29（6.8%），原因是未遵守既定方案。该队列中有34次UTI发作：G1组5/27（18.5%），G2组11/26（42.3%），G3组18/27（48.1%），至少有一次感染发作（p<0.05）。
结论
这些数据表明，每日饮用浓缩蔓越莓汁可显著预防儿童有症状UTI的复发。
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