Hudson Rachel E, Job Kathleen M, Sayre Casey L, Krepkova Lubov V, Sherwin Catherine M, Enioutina Elena Y
Department of Pediatrics, Post-Doctoral Fellow, Division of Clinical Pharmacology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Department of Pediatrics, Research Assistant Professor, Division of Clinical Pharmacology, University of Utah School of Medicine, Salt Lake City, UT, United States.
Front Pharmacol. 2022 Apr 27;13:883216. doi: 10.3389/fphar.2022.883216. eCollection 2022.
Urinary tract infections (UTIs) are a significant clinical problem that pregnant women and children commonly experience. is the primary causative organism, along with several other gram-negative and gram-positive bacteria. Antimicrobial drugs are commonly prescribed to treat UTIs in these patients. Conventional treatment can range from using broad-spectrum antimicrobial drugs for empirical or prophylactic therapy or patient-tailored therapy based on urinary cultures and sensitivity to prospective antibiotics. The ongoing emergence of multi-drug resistant pathogens has raised concerns related to commonly prescribed antimicrobial drugs such as those used routinely to treat UTIs. Consequently, several natural medicines have been explored as potential complementary therapies to improve health outcomes in patients with UTIs. This review discusses the effectiveness of commonly used natural products such as cranberry juice/extracts, ascorbic acid, hyaluronic acid, probiotics, and multi-component formulations intended to treat and prevent UTIs. The combination of natural products with prescribed antimicrobial treatments and use of formulations that contained high amounts of cranberry extracts appear to be most effective in preventing recurrent UTIs (RUTIs). The incorporation of natural products like cranberry, hyaluronic acid, ascorbic acid, probiotics, Canephron N, and Cystenium II to conventional treatments of acute UTIs or as a prophylactic regimen for treatment RUTIs can benefit both pregnant women and children. Limited information is available on the safety of natural products in these patients' populations. However, based on limited historical information, these remedies appear to be safe and well-tolerated by patients.
尿路感染（UTIs）是孕妇和儿童常见的一个重要临床问题。大肠杆菌是主要致病微生物，还有其他几种革兰氏阴性菌和革兰氏阳性菌。抗菌药物通常用于治疗这些患者的尿路感染。传统治疗方法包括使用广谱抗菌药物进行经验性或预防性治疗，或根据尿培养和对预期抗生素的敏感性进行个体化治疗。多重耐药病原体的不断出现引发了人们对常用抗菌药物的担忧，比如那些常规用于治疗尿路感染的药物。因此，人们探索了几种天然药物作为潜在的辅助疗法，以改善尿路感染患者的健康状况。这篇综述讨论了常用天然产品的有效性，如蔓越莓汁/提取物、抗坏血酸、透明质酸、益生菌以及用于治疗和预防尿路感染的多成分制剂。天然产品与处方抗菌治疗相结合，以及使用含有大量蔓越莓提取物的制剂，似乎在预防复发性尿路感染（RUTIs）方面最有效。将蔓越莓、透明质酸、抗坏血酸、益生菌、Canephron N和Cystenium II等天然产品纳入急性尿路感染的传统治疗或作为复发性尿路感染治疗的预防方案，对孕妇和儿童都有益。关于这些天然产品在这些患者群体中的安全性信息有限。然而，根据有限的历史信息，这些疗法似乎是安全的，并且患者耐受性良好。
