Division of Hematology and Oncology, Mayo Clinic, Scottsdale, Arizona 85259, USA.
J Palliat Med. 2009 Nov;12(11):1061-5. doi: 10.1089/jpm.2009.9936.
Bisphosphonates have become an important treatment for the palliation of metastatic bone disease. Their increasing use has lead to the recognition of toxicities that can lead to substantial morbidity for the patient with advanced cancer. This case presentation highlights toxicities associated with bisphosphonate use and provides some guidelines on the use of bisphosphonates and management of these toxicities.
双膦酸盐已成为缓解转移性骨病的重要治疗方法。随着其使用的增加，人们认识到其可能导致晚期癌症患者发生严重疾病。本病例介绍强调了与双膦酸盐使用相关的毒性，并提供了一些关于双膦酸盐使用和这些毒性管理的指导原则。
