Tsukahara Kiyoaki, Sugitani Iwao, Kawabata Kazuyoshi
Head and Neck Oncology Department, Cancer Institute Hospital, Tokyo, Japan.
Acta Otolaryngol. 2009 Dec;129(12):1498-502. doi: 10.3109/00016480902725239.
Patients showed improved quality of life following tracheal shaving and the carcinoma was well controlled locally, as long as invasion had not progressed to the mucosal surface of the trachea. However, compared with papillary thyroid carcinoma (PTC) with no tracheal invasion, metastasis was common and invasion of organs other than the trachea was frequent, putting many patients into the high-risk group. The clinical course for such patients thus requires careful monitoring, with particular attention to metastasis to other locations. Tracheal shaving can be recommended for patients with PTC with tracheal invasion.
Macroscopically, in cases where invasion into the trachea has not reached the tracheal mucosa surface, we perform tracheal surface resection (tracheal shaving). We retrospectively investigated rates of local control, metastasis and survival in patients who had undergone tracheal shaving.
Subjects comprised 22 patients with PTC who underwent tracheal shaving between January 1994 and December 2005.
Local control was achieved in 21 patients (95%), and metastasis was seen in 6 patients (27%). With two patients dying from causes other than cancer, 5- and 10-year survival rates were 93% and 41%, respectively. The two surviving patients are still cancer-bearing.
只要肿瘤浸润尚未进展至气管黏膜表面,气管削除术后患者的生活质量有所改善,且肿瘤在局部得到良好控制。然而,与无气管浸润的乳头状甲状腺癌(PTC)相比,转移较为常见,气管以外器官的浸润也很频繁,许多患者因此被归入高危组。因此,这类患者的临床病程需要密切监测,尤其要注意其他部位的转移情况。对于有气管浸润的PTC患者,可推荐行气管削除术。
在肉眼观察下,当肿瘤浸润未到达气管黏膜表面时,我们进行气管表面切除术(气管削除术)。我们回顾性研究了接受气管削除术患者的局部控制率、转移率和生存率。
研究对象包括1994年1月至2005年12月期间接受气管削除术的22例PTC患者。
21例患者(95%)实现了局部控制,6例患者(27%)出现转移。2例患者死于癌症以外的原因,5年和10年生存率分别为93%和41%。两名存活患者仍患有癌症。