Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey.
Int J Neurosci. 2009;119(9):1303-18. doi: 10.1080/00207450802333672.
In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains. ETOH were administered as increasing concentrations of 2.4%-7.2% (v/v) gradually for 21 days. Immunocytochemistry revealed that chronic-ETOH treatment increased synthesis of GFAP. The increase in the diameter and the number of GFAP (+) cells were statistically significant compared with the control group (p <. 05). An increase of GFAP immunoreactivity was evident in various white matter and gray matter structures. We concluded that functional astrocytic cells responded to chronic ETOH exposure by increasing the synthesis of GFAP.
在本研究中，我们研究了慢性乙醇（ETOH）处理对成年大鼠大脑中胶质纤维酸性蛋白（GFAP）免疫反应性的影响。ETOH 以逐渐增加的浓度 2.4％-7.2％（v/v）给药 21 天。免疫细胞化学显示，慢性 ETOH 处理增加了 GFAP 的合成。与对照组相比，GFAP（+）细胞的直径和数量增加具有统计学意义（p<.05）。GFAP 免疫反应性在各种白质和灰质结构中均明显增加。我们得出结论，功能性星形胶质细胞通过增加 GFAP 的合成对慢性 ETOH 暴露作出反应。
