Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48108, USA.
J Psychosom Obstet Gynaecol. 2009 Dec;30(4):255-61. doi: 10.3109/01674820903276446.
The purpose of this study was to examine problems related to alcohol use as reported covering the year prior to pregnancy in a general prenatal care seeking sample. The relationship of alcohol use to a number of pregnancy and birth complications (premature rupture of membrane, birthweight, weeks gestation and APGAR) was examined.
A total of 940 prenatal care-seeking women completed the TWEAK, a brief measure of alcohol use problems during the previous year. Measures were completed by women at an average of 25 weeks gestation (SD = 9.7) in the waiting areas of university-affiliated obstetrics clinics in the US. Pregnancy and birth complications were gathered via medical record search and completed on all cases.
Controlling for cigarette use and key demographic variables, only pre-pregnancy elevated TWEAK (> or =2) was significantly and consistently related to each obstetrical outcome in multivariate analyses in the total sample. Analyses showed that pre-pregnancy TWEAK was related to PROM and lower birthweight among the sample of women (n = 800) who reported no actual alcohol use during pregnancy.
Results suggest that a brief screening for alcohol use problems may detect women either in early pregnancy or pre-conceptually, that may be at risk for potentially harmful pregnancy and birth outcomes, including women who deny prenatal alcohol use.
本研究旨在调查在一般产前保健就诊样本中，与怀孕前一年报告的酒精使用相关的问题。研究还考察了酒精使用与一些妊娠和分娩并发症（胎膜早破、出生体重、孕周和阿普加评分）之间的关系。
共有 940 名寻求产前保健的女性完成了 TWEAK，这是一种在过去一年中衡量酒精使用问题的简短方法。这些措施是由女性在美国大学附属妇产科诊所的候诊区平均在 25 周妊娠（SD=9.7）时完成的。通过医疗记录搜索收集了妊娠和分娩并发症，并完成了所有病例。
在控制吸烟和关键人口统计学变量的情况下，仅在多元分析中，孕前 TWEAK（>或=2）与所有产科结局均显著相关。分析表明，在报告怀孕期间没有实际饮酒的 800 名女性样本中，孕前 TWEAK 与 PROM 和较低的出生体重有关。
结果表明，简短的酒精使用问题筛查可能会发现处于早孕或孕前阶段的女性，这些女性可能存在潜在有害的妊娠和分娩结局风险，包括否认产前饮酒的女性。
