Karpas A, Sandler R M, Thorburn R J
Br J Cancer. 1977 Aug;36(2):177-86. doi: 10.1038/bjc.1977.175.
Cultured cells established from the bone marrow of a child with null-cell acute lymphoblastic leukaemia (ALL) have been studied. After 8 months in vitro, the cytological, cytochemical and immunological properties of the cultured cells were very similar to those of the patient's cells. Many of the cultured cells had morphological and cytogenetic abnormalities often found in acute leukaemia. The cells were EBNA-negative. This unique culture of ALL-derived null cells might provide information as to the aetiology and origin of malignant cells.
对一名无细胞急性淋巴细胞白血病（ALL）患儿骨髓来源的培养细胞进行了研究。体外培养8个月后，培养细胞的细胞学、细胞化学和免疫学特性与患者细胞非常相似。许多培养细胞具有急性白血病中常见的形态学和细胞遗传学异常。这些细胞EBNA呈阴性。这种源自ALL的独特无细胞培养可能为恶性细胞的病因和起源提供信息。
