Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.
作者信息
Broek D, Bartlett R, Crawford K, Nurse P
机构信息
Biochemistry Department, University of Oxford, UK.
出版信息
Nature. 1991 Jan 31;349(6308):388-93. doi: 10.1038/349388a0.
DOI:10.1038/349388a0
PMID:1992340
Abstract
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
摘要
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