Broek D, Bartlett R, Crawford K, Nurse P
Biochemistry Department, University of Oxford, UK.
Nature. 1991 Jan 31;349(6308):388-93. doi: 10.1038/349388a0.
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
