鉴定DNA疫苗接种后具有保护作用的西部马脑炎病毒结构蛋白。
Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination.
作者信息
Gauci Penelope J, Wu Josh Q H, Rayner George A, Barabé Nicole D, Nagata Leslie P, Proll David F
机构信息
Biological Countermeasures, Human Protection and Performance Division, Defence Science & Technology Organisation, 506 Lorimer St., Fishermans Bend, VIC 3207, Australia.
出版信息
Clin Vaccine Immunol. 2010 Jan;17(1):176-9. doi: 10.1128/CVI.00377-09. Epub 2009 Nov 18.
Abstract
DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.
摘要
对编码西部马脑炎病毒结构蛋白不同部分的DNA疫苗在该病毒100%致死性小鼠模型中的保护效果进行了测试。DNA疫苗编码的6K-E1结构蛋白对同源毒株的攻击提供了完全保护，对异源毒株的攻击提供了有限保护。
相似文献
1
Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination.鉴定DNA疫苗接种后具有保护作用的西部马脑炎病毒结构蛋白。
Clin Vaccine Immunol. 2010 Jan;17(1):176-9. doi: 10.1128/CVI.00377-09. Epub 2009 Nov 18.
2
Efficacy of DNA vaccination against western equine encephalitis virus infection.DNA疫苗预防西部马脑炎病毒感染的效力
Vaccine. 2005 Mar 18;23(17-18):2280-3. doi: 10.1016/j.vaccine.2005.01.032.
3
A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge.单价和三价 MVA 疫苗可完全保护小鼠免受致命委内瑞拉、西部和东部马脑炎病毒气溶胶挑战。
Front Immunol. 2021 Jan 19;11:598847. doi: 10.3389/fimmu.2020.598847. eCollection 2020.
4
Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.嵌合甲型病毒候选疫苗可保护小鼠免受西部马脑炎病毒的鼻内攻击。
Vaccine. 2009 Jul 9;27(32):4309-19. doi: 10.1016/j.vaccine.2009.05.011. Epub 2009 May 27.
5
Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with western and eastern equine encephalitis viruses.脂质体-抗原-核酸复合物可保护小鼠免受西部和东部马脑炎病毒的致死性攻击。
J Virol. 2014 Feb;88(3):1771-80. doi: 10.1128/JVI.02297-13. Epub 2013 Nov 20.
6
Envelope protein E1 as vaccine target for western equine encephalitis virus.包膜蛋白 E1 作为西方马脑炎病毒的疫苗靶标。
Vaccine. 2011 Jan 17;29(4):813-20. doi: 10.1016/j.vaccine.2010.11.009. Epub 2010 Dec 3.
7
Complete protection of mice against a lethal dose challenge of western equine encephalitis virus after immunization with an adenovirus-vectored vaccine.用腺病毒载体疫苗免疫小鼠后，其对西部马脑炎病毒致死剂量攻击具有完全保护作用。
Vaccine. 2007 May 30;25(22):4368-75. doi: 10.1016/j.vaccine.2007.03.042. Epub 2007 Apr 11.
8
Single-dose, fast-acting vaccine candidate against western equine encephalitis virus completely protects mice from intranasal challenge with different strains of the virus.针对西部马脑炎病毒的单剂量速效候选疫苗可完全保护小鼠免受不同病毒株的鼻内攻击。
Vaccine. 2007 Aug 14;25(33):6271-6. doi: 10.1016/j.vaccine.2007.05.054. Epub 2007 Jun 14.
9
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses.委内瑞拉马脑炎病毒和西部马脑炎病毒E1脂质体抗原核酸复合物可保护小鼠免受多种甲病毒的致死性攻击。
Virology. 2016 Dec;499:30-39. doi: 10.1016/j.virol.2016.08.023. Epub 2016 Sep 12.
10
Recombinant chimeric western and eastern equine encephalitis viruses as potential vaccine candidates.重组嵌合西尼罗河病毒和东部马脑炎病毒作为潜在的疫苗候选物。
Virology. 2002 Oct 25;302(2):299-309. doi: 10.1006/viro.2002.1677.
引用本文的文献
1
Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape.深入了解抗体介导的甲病毒免疫和疫苗开发前景。
Microorganisms. 2021 Apr 22;9(5):899. doi: 10.3390/microorganisms9050899.
2
Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses.针对委内瑞拉、东部和西部马脑炎病毒的疫苗进展
Vaccines (Basel). 2020 Jun 3;8(2):273. doi: 10.3390/vaccines8020273.
3
A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges.肌肉内电穿孔传递的多价丙型肝炎病毒 DNA 疫苗在小鼠和兔中引发强大且持久的病毒特异性免疫应答，并完全保护小鼠免受致死性委内瑞拉、西部和东部马脑炎病毒气溶胶挑战。
J Immunol Res. 2018 Jun 3;2018:8521060. doi: 10.1155/2018/8521060. eCollection 2018.
4
Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with western and eastern equine encephalitis viruses.脂质体-抗原-核酸复合物可保护小鼠免受西部和东部马脑炎病毒的致死性攻击。
J Virol. 2014 Feb;88(3):1771-80. doi: 10.1128/JVI.02297-13. Epub 2013 Nov 20.
5
Factors affecting recombinant Western equine encephalitis virus glycoprotein production in the baculovirus system.杆状病毒系统中影响重组西部马脑炎病毒糖蛋白产生的因素。
Protein Expr Purif. 2011 Dec;80(2):274-82. doi: 10.1016/j.pep.2011.08.002. Epub 2011 Aug 16.
本文引用的文献
1
New insights on adenovirus as vaccine vectors.腺病毒作为疫苗载体的新见解。
Mol Ther. 2009 Aug;17(8):1333-9. doi: 10.1038/mt.2009.130. Epub 2009 Jun 9.
2
Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model.远交系小鼠模型中西尼罗马脑炎病毒分离株的毒力变异
J Gen Virol. 2009 Aug;90(Pt 8):1848-1858. doi: 10.1099/vir.0.008656-0. Epub 2009 Apr 29.
3
Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription.委内瑞拉马脑炎病毒衣壳蛋白在抑制细胞转录中的功能分析
J Virol. 2007 Dec;81(24):13552-65. doi: 10.1128/JVI.01576-07. Epub 2007 Oct 3.
4
Infectivity variation and genetic diversity among strains of Western equine encephalitis virus.西部马脑炎病毒毒株间的传染性变异和遗传多样性。
J Gen Virol. 2006 Aug;87(Pt 8):2353-2361. doi: 10.1099/vir.0.81815-0.
5
Boosting with an adenovirus-based vaccine improves protective efficacy against Venezuelan equine encephalitis virus following DNA vaccination.基于腺病毒的疫苗进行加强免疫可提高DNA疫苗接种后对委内瑞拉马脑炎病毒的保护效力。
Vaccine. 2006 Apr 24;24(17):3440-5. doi: 10.1016/j.vaccine.2006.02.020. Epub 2006 Feb 21.
6
Efficacy of DNA vaccination against western equine encephalitis virus infection.DNA疫苗预防西部马脑炎病毒感染的效力
Vaccine. 2005 Mar 18;23(17-18):2280-3. doi: 10.1016/j.vaccine.2005.01.032.
7
Intranasal immunisation with defective adenovirus serotype 5 expressing the Venezuelan equine encephalitis virus E2 glycoprotein protects against airborne challenge with virulent virus.用表达委内瑞拉马脑炎病毒E2糖蛋白的缺陷型5型腺病毒进行鼻内免疫可抵御强毒病毒的空气传播攻击。
Vaccine. 2005 Feb 18;23(13):1615-23. doi: 10.1016/j.vaccine.2004.06.056.
8
Evaluation of a Western Equine Encephalitis recombinant E1 protein for protective immunity and diagnostics.对一种用于保护性免疫和诊断的西部马脑炎重组E1蛋白的评估。
Antiviral Res. 2004 Nov;64(2):85-92. doi: 10.1016/j.antiviral.2004.06.008.
9
DNA vaccine strategies: candidates for immune modulation and immunization regimens.DNA疫苗策略：免疫调节候选物和免疫方案
Methods. 2003 Nov;31(3):207-16. doi: 10.1016/s1046-2023(03)00135-x.
10
Construction and characterization of monoclonal antibodies against western equine encephalitis virus.抗西部马脑炎病毒单克隆抗体的构建与鉴定
Hybridoma. 2000 Apr;19(2):121-7. doi: 10.1089/02724570050031158.
Zotero 插件