Department of Psychiatry and Psychotherapy, University of Munster, Germany.
Pharmacopsychiatry. 2009 Nov;42(6):266-9. doi: 10.1055/s-0029-1241798. Epub 2009 Nov 18.
There is evidence that a decreased GABAergic tone plays a role in the pathophysiology of panic disorder (PD). Selective GABAergic treatment has been suggested as a new therapeutic strategy in PD. In this pilot-study anxiolytic effects of the GABA reuptake inhibitor tiagabine (TGB) were investigated in PD.
A total of 19 patients were treated with TGB (n=10) or placebo (n=9) for 4 weeks. PAS, HAM-A, and CGI ratings were administered every week. To further assess specific antipanic activity, panic challenges with CCK-4 were carried out in single subjects.
Although there was a significant reduction of clinical rating scores over time, no differences were detected between the groups. However, during challenge experiments TGB treated subjects showed decreased sensitivity to CCK-4.
Whereas tiagabine did not show beneficial effects on clinical symptoms in PD compared to placebo, results of challenge experiments suggest effects of TGB on sensitivity to experimentally induced panic.
有证据表明，γ-氨基丁酸能张力降低在惊恐障碍（PD）的病理生理学中起作用。选择性 GABA 能治疗已被提议作为 PD 的新治疗策略。在这项初步研究中，研究了 GABA 再摄取抑制剂替加滨（TGB）在 PD 中的抗焦虑作用。
共有 19 名患者接受 TGB（n=10）或安慰剂（n=9）治疗 4 周。每周进行 PAS、HAM-A 和 CGI 评分。为了进一步评估特定的抗惊恐活性，在单个受试者中进行了 CCK-4 的惊恐挑战。
尽管临床评分随时间显著降低，但组间无差异。然而，在挑战实验中，TGB 治疗的受试者对 CCK-4 的敏感性降低。
虽然替加滨与安慰剂相比，在 PD 中的临床症状没有显示出有益的效果，但挑战实验的结果表明 TGB 对实验诱导的惊恐敏感性有影响。
