Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.
Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toruń, Poland.
Int J Mol Sci. 2020 Oct 30;21(21):8099. doi: 10.3390/ijms21218099.
Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart's work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process.
药品安全性评估是药学和医学中一个快速发展的领域。新的化合物毒性测试高级指南需要专门的工具，这些工具能够快速可靠地提供有关测试药物的信息。离子通道代表着第三大目标。正如文献中提到的，离子通道是心脏工作不可或缺的一部分。本文收集了有关心脏毒性测试指南和测试方法的最重要信息。重点关注了在这个过程中选定的离子通道的作用。
