细胞毒性T细胞介导的肽诱导抗病毒保护作用。
Peptide-induced antiviral protection by cytotoxic T cells.
作者信息
Schulz M, Zinkernagel R M, Hengartner H
机构信息
Institute of Pathology, University Hospital, Zürich, Switzerland.
出版信息
Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):991-3. doi: 10.1073/pnas.88.3.991.
Abstract
A specific antiviral cytotoxic immune response in vivo could be induced by the subcutaneous injection of the T-cell epitope of the lymphocytic choriomeningitis virus (LCMV) nucleoprotein as an unmodified free synthetic peptide (Arg-Pro-Gln-Ala-Ser-Gly-Val-Tyr-Met-Gly-Asn-Leu-Thr-Ala-Gln) emulsified in incomplete Freund's adjuvant. This immunization rendered mice into a LCMV-specific protective state as shown by the inhibition of LCMV replication in spleens of such mice. The protection level of these mice correlated with the ability to respond to the peptide challenge by CD8+ virus-specific cytotoxic T cells. This is a direct demonstration that peptide vaccines can be antivirally protective in vivo, thus encouraging further search for appropriate mixtures of stable peptides that may be used as T-cell vaccines.
摘要
通过皮下注射淋巴细胞性脉络丛脑膜炎病毒（LCMV）核蛋白的T细胞表位，以未修饰的游离合成肽（精氨酸-脯氨酸-谷氨酰胺-丙氨酸-丝氨酸-甘氨酸-缬氨酸-酪氨酸-甲硫氨酸-甘氨酸-天冬酰胺-亮氨酸-苏氨酸-丙氨酸-谷氨酰胺）乳化于不完全弗氏佐剂中，可在体内诱导出特异性抗病毒细胞毒性免疫反应。这种免疫使小鼠进入LCMV特异性保护状态，如在此类小鼠脾脏中LCMV复制受到抑制所示。这些小鼠的保护水平与CD8 +病毒特异性细胞毒性T细胞对肽攻击的反应能力相关。这直接证明肽疫苗在体内可具有抗病毒保护作用，从而鼓励进一步寻找可用作T细胞疫苗的合适稳定肽混合物。
相似文献
1
Peptide-induced antiviral protection by cytotoxic T cells.细胞毒性T细胞介导的肽诱导抗病毒保护作用。
Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):991-3. doi: 10.1073/pnas.88.3.991.
2
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.通过用游离合成肽进行体内致敏诱导的抗病毒细胞毒性T细胞反应。
J Exp Med. 1990 May 1;171(5):1815-20. doi: 10.1084/jem.171.5.1815.
3
In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity.体内高亲和力、高频细胞毒性T淋巴细胞反应的诱导与抗病毒保护性免疫相关。
J Virol. 2000 Jul;74(13):5769-75. doi: 10.1128/jvi.74.13.5769-5775.2000.
4
Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein.通过用表达淋巴细胞性脉络丛脑膜炎病毒（LCMV-WE）核蛋白或糖蛋白的痘苗重组病毒免疫，对小鼠进行抗病毒保护并预防淋巴细胞性脉络丛脑膜炎或局部足垫肿胀反应。
Eur J Immunol. 1989 Mar;19(3):417-24. doi: 10.1002/eji.1830190302.
5
Attenuated Listeria monocytogenes as a live vector for induction of CD8+ T cells in vivo: a study with the nucleoprotein of the lymphocytic choriomeningitis virus.减毒单核细胞增生李斯特菌作为体内诱导CD8 + T细胞的活载体：以淋巴细胞性脉络丛脑膜炎病毒核蛋白进行的研究
Int Immunol. 1995 May;7(5):797-805. doi: 10.1093/intimm/7.5.797.
6
Direct ex vivo kinetic and phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization.DNA免疫诱导的CD8(+) T细胞反应的直接离体动力学和表型分析。
J Virol. 2000 Sep;74(18):8286-91. doi: 10.1128/jvi.74.18.8286-8291.2000.
7
Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.通过接种重组单核细胞增生李斯特菌实现抗病毒细胞毒性T细胞记忆
J Virol. 1996 May;70(5):2902-10. doi: 10.1128/JVI.70.5.2902-2910.1996.
8
Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection.表达免疫显性T细胞表位的分子工程疫苗可诱导细胞毒性T淋巴细胞，从而提供针对致命病毒感染的保护。
J Virol. 1989 Oct;63(10):4311-6. doi: 10.1128/JVI.63.10.4311-4316.1989.
9
Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus.淋巴细胞性脉络丛脑膜炎病毒细胞毒性T细胞逃逸突变体的免疫生物学
J Virol. 1995 Apr;69(4):2187-93. doi: 10.1128/JVI.69.4.2187-2193.1995.
引用本文的文献
1
Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice.呈现来自HIV-1包膜的P18I10和T20肽的嵌合人乳头瘤病毒16型病毒样颗粒在BALB/c小鼠中诱导HPV16和HIV-1特异性体液免疫和T细胞介导的免疫。
Vaccines (Basel). 2022 Dec 21;11(1):15. doi: 10.3390/vaccines11010015.
2
Structural Analyses of a Dominant Cryptosporidium parvum Epitope Presented by H-2K Offer New Options To Combat Cryptosporidiosis.结构分析表明，由 H-2K 呈递的优势隐孢子虫表位为抗隐孢子虫病提供了新选择。
mBio. 2023 Feb 28;14(1):e0266622. doi: 10.1128/mbio.02666-22. Epub 2023 Jan 5.
3
Peptides for Vaccine Development.用于疫苗开发的肽。
ACS Appl Bio Mater. 2022 Mar 21;5(3):905-944. doi: 10.1021/acsabm.1c01238. Epub 2022 Feb 23.
4
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives.合成长肽个性化新抗原疫苗接种：最新进展与未来展望。
Theranostics. 2020 May 15;10(13):6011-6023. doi: 10.7150/thno.38742. eCollection 2020.
5
Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope.MHC-I 分子 BF2*1501 的结构揭示了 H5N1 病毒衍生表位的优先呈递。
J Biol Chem. 2020 Apr 17;295(16):5292-5306. doi: 10.1074/jbc.RA120.012713. Epub 2020 Mar 9.
6
Anti- antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes.抗抗体附着于小鼠癌细胞系，但不附着于正常小鼠淋巴细胞。
Biomed Rep. 2019 Mar;10(3):183-188. doi: 10.3892/br.2019.1186. Epub 2019 Jan 17.
7
Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8 T and T Cell Responses against Herpesvirus Infection and Disease.激光辅助肽疫苗促进树突状细胞向皮肤迁移，并增强针对疱疹病毒感染和疾病的保护性CD8 T细胞和T细胞反应。
J Virol. 2018 Mar 28;92(8). doi: 10.1128/JVI.02156-17. Print 2018 Apr 15.
8
T cell responses to viral infections - opportunities for Peptide vaccination.T细胞对病毒感染的反应——肽疫苗接种的机遇
Front Immunol. 2014 Apr 16;5:171. doi: 10.3389/fimmu.2014.00171. eCollection 2014.
9
Targeting CD137 enhances vaccine-elicited anti-respiratory syncytial virus CD8+ T cell responses in aged mice.靶向 CD137 增强了老年小鼠疫苗诱导的抗呼吸道合胞病毒 CD8+ T 细胞应答。
J Immunol. 2014 Jan 1;192(1):293-9. doi: 10.4049/jimmunol.1300453. Epub 2013 Nov 27.
10
Mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections.眼部和生殖器单纯疱疹病毒感染的黏膜疱疹免疫及免疫病理学
Clin Dev Immunol. 2012;2012:149135. doi: 10.1155/2012/149135. Epub 2012 Dec 24.
本文引用的文献
1
The virology and immunobiology of lymphocytic choriomeningitis virus infection.淋巴细胞性脉络丛脑膜炎病毒感染的病毒学与免疫生物学
Adv Immunol. 1980;30:275-331. doi: 10.1016/s0065-2776(08)60197-2.
2
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.通过体内消除T细胞亚群进行单克隆抗体治疗。
Nature. 1984;312(5994):548-51. doi: 10.1038/312548a0.
3
Synthetic peptides as vaccines.
Nature. 1987;330(6144):106-7. doi: 10.1038/330106b0.
4
Induction of class I MHC-restricted, peptide-specific cytolytic T lymphocytes by peptide priming in vivo.通过体内肽引发诱导I类主要组织相容性复合体（MHC）限制的、肽特异性细胞毒性T淋巴细胞。
J Immunol. 1989 Aug 15;143(4):1094-100.
5
Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.通过体内肽免疫诱导卵清蛋白特异性细胞毒性T细胞。
J Exp Med. 1989 Mar 1;169(3):603-12. doi: 10.1084/jem.169.3.603.
6
In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine.用合成脂肽疫苗在体内引发病毒特异性细胞毒性T淋巴细胞。
Nature. 1989 Nov 30;342(6249):561-4. doi: 10.1038/342561a0.
7
Major histocompatibility complex--dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease.淋巴细胞性脉络丛脑膜炎病毒核蛋白的主要组织相容性复合体依赖性T细胞表位及其对病毒性疾病的保护能力
Eur J Immunol. 1989 Sep;19(9):1657-67. doi: 10.1002/eji.1830190921.
8
Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein.通过用表达淋巴细胞性脉络丛脑膜炎病毒（LCMV-WE）核蛋白或糖蛋白的痘苗重组病毒免疫，对小鼠进行抗病毒保护并预防淋巴细胞性脉络丛脑膜炎或局部足垫肿胀反应。
Eur J Immunol. 1989 Mar;19(3):417-24. doi: 10.1002/eji.1830190302.
9
Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus.淋巴细胞性脉络丛脑膜炎病毒糖蛋白中主要细胞毒性T淋巴细胞表位的分子定义。
J Virol. 1988 Mar;62(3):687-95. doi: 10.1128/JVI.62.3.687-695.1988.
10
Cytotoxic T lymphocytes against a soluble protein.
Nature. 1987;329(6138):449-51. doi: 10.1038/329449a0.
Zotero 插件