Romagnoli Costantino, Bersani Iliana, Rubortone Serena Antonia, Lacerenza Serafina, De Carolis Maria Pia
Department of Paediatrics and Division of Neonatology, Catholic University of Sacred Heart, Rome, Italy.
J Matern Fetal Neonatal Med. 2011 Nov;24 Suppl 3:10-3. doi: 10.3109/14767058.2011.604987. Epub 2011 Sep 23.
Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.
动脉导管未闭（PDA）会使早产儿的临床病程复杂化。非甾体类抗炎药，尤其是吲哚美辛和布洛芬，已被广泛用于预防和治疗PDA。吲哚美辛和布洛芬的短期疗效相当，但布洛芬的安全性更高。与吲哚美辛相比，布洛芬的临床胃肠道和肾脏副作用较少，即便有亚临床潜在影响的报道。作为预防性用药时，布洛芬与吲哚美辛不同，对预防脑室内出血没有作用。鉴于这两种药物都有潜在的不良反应，强烈建议在治疗期间及之后进行仔细监测。
