多发性硬化症患者脑脊液壳三糖苷酶指数升高。
Increased cerebrospinal fluid chitotriosidase index in patients with multiple sclerosis.
机构信息
Department of Neurology, Donders Centre for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
出版信息
Acta Neurol Scand. 2010 May;121(5):309-14. doi: 10.1111/j.1600-0404.2009.01242.x. Epub 2009 Nov 19.
OBJECTIVE
To investigate chitotriosidase (CTTS) activity in serum and cerebrospinal fluid (CSF) in multiple sclerosis (MS) patients in relation to disease course and CSF markers for immune activation or inflammation.
MATERIALS AND METHODS
We studied 80 patients with relapsing-remitting MS (RRMS), 24 with secondary progressive MS (SPMS), 20 with primary progressive MS (PPMS) and 29 patients with other neurological disorders (OND). We measured CTTS activity and studied the correlation with CSF mononuclear cell count (MNC) and intrathecal IgG production.
RESULTS
CTTS activity was significantly higher in CSF, but not in serum, from the total MS group compared with OND and controls. In RRMS and SPMS CTTS, index was increased compared with controls (RRMS, 0.10 +/- 0.21; SPMS, 0.10 +/- 0.15; controls, 0.021 +/- 0.020), but not in PPMS (0.061 +/- 0.052). CTTS index was higher in MS patients with elevated MNC or CSF-restricted oligoclonal IgG bands than in MS patients without these CSF findings.
CONCLUSIONS
CTTS index is elevated in RRMS and SPMS. The CTTS index is related to CSF markers of inflammation or immune activation.
目的
研究多发性硬化症（MS）患者血清和脑脊液（CSF）中的壳三糖酶（CTTS）活性与疾病进程及 CSF 中免疫激活或炎症标志物的关系。
材料和方法
我们研究了 80 例复发缓解型 MS（RRMS）患者、24 例继发进展型 MS（SPMS）患者、20 例原发进展型 MS（PPMS）患者和 29 例其他神经系统疾病（OND）患者。我们测量了 CTTS 活性，并研究了其与 CSF 单核细胞计数（MNC）和鞘内 IgG 产生的相关性。
结果
与 OND 和对照组相比，总 MS 组 CSF 中的 CTTS 活性明显升高，但血清中无此变化。RRMS 和 SPMS 中的 CTTS 指数与对照组相比有所增加（RRMS，0.10 +/- 0.21；SPMS，0.10 +/- 0.15；对照组，0.021 +/- 0.020），但 PPMS 中则无此变化（0.061 +/- 0.052）。CSF 中 MNC 升高或 CSF 中受限寡克隆 IgG 带的 MS 患者的 CTTS 指数高于无这些 CSF 发现的 MS 患者。
结论
RRMS 和 SPMS 中 CTTS 指数升高。CTTS 指数与 CSF 炎症或免疫激活标志物相关。
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