Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528, USA.
Toxicon. 2010 Aug 15;56(2):137-49. doi: 10.1016/j.toxicon.2009.11.007. Epub 2009 Nov 17.
Herein, we describe advancements in monitoring of brevetoxins in molluscan shellfish, with respect to exposure management and control of neurotoxic shellfish poisoning (NSP). Current knowledge of the fate of brevetoxins in molluscan shellfish, and the toxic potency of brevetoxin metabolites, is presented. We review rapid assays for measuring composite brevetoxins, and methodology for measuring constituent brevetoxins, in contaminated shellfish. The applicability of in vitro methods for estimating brevetoxin burden and composite toxicity in shellfish is assessed. Specific and measurable biomarkers of brevetoxin exposure and toxicity in shellfish, and of human intoxication, are described. Their utility in regulatory monitoring of toxic shellfish and in clinical diagnosis of NSP is evaluated.
在此，我们描述了监测贝类生物中短裸甲藻毒素的进展，涉及到暴露管理和控制神经毒性贝类中毒（NSP）。本文介绍了贝类生物中短裸甲藻毒素的命运和短裸甲藻毒素代谢物的毒性效力的现有知识。我们回顾了测量贝类生物中复合短裸甲藻毒素和测量污染贝类中短裸甲藻毒素成分的快速检测方法。评估了体外方法在估计贝类生物中短裸甲藻毒素负担和复合毒性方面的适用性。描述了贝类生物中短裸甲藻暴露和毒性以及人类中毒的特异性和可测量生物标志物。评估了它们在贝类生物中毒监管监测和 NSP 临床诊断中的应用。
