Doshi H M, Schochet S S, Gold M, Nugent G R
Department of Pathology, West Virginia University Hospital, Morgantown.
Am J Clin Pathol. 1991 Feb;95(2):228-32. doi: 10.1093/ajcp/95.2.228.
Granulocytic sarcomas are rare tumors composed of granulocytic precursor cells. They are most commonly encountered in patients with acute myelogenous leukemias and myeloproliferative disorders in blast crisis. Rarely, patients presenting with granulocytic sarcoma show no evidence of acute leukemia. The authors report an aleukemic patient with acute paraparesis from an epidural granulocytic sarcoma. Only five such cases have been reported previously. Immunoperoxidase stain for lysozyme and chloroacetate esterase stain were used to prove the myeloid origin of the tumor cells.
粒细胞肉瘤是由粒细胞前体细胞组成的罕见肿瘤。它们最常见于急性髓系白血病和处于原始细胞危象的骨髓增殖性疾病患者。很少有表现为粒细胞肉瘤的患者没有急性白血病的证据。作者报告了一例因硬膜外粒细胞肉瘤导致急性截瘫的无白血病患者。此前仅报道过5例此类病例。使用溶菌酶免疫过氧化物酶染色和氯乙酸酯酶染色来证实肿瘤细胞的髓系起源。