Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Eur J Surg Oncol. 2010 Jan;36(1):6-15. doi: 10.1016/j.ejso.2009.10.014. Epub 2009 Nov 18.
Improved visualization of surgical targets inside of the patient helps to improve radical resection of the tumor while sparing healthy surrounding tissue. In order to achieve an image, optical contrast must be generated by properties intrinsic to the tissue, or require the attachment of special visualization labels to the tumor. In this overview the current status of the clinical use of fluorescent dyes and probes are reviewed.
In this review, all experimental and clinical studies concerning fluorescent imaging were included. In addition, in the search for the optimal fluorescent imaging modality, all characteristics of a fluorescent dye were described.
Although the technique of imaging through fluorescence sounds promising and several animal models show efficacy, official approval of these agents for further clinical evaluation, is eagerly awaited.
提高患者体内手术目标的可视化程度有助于提高肿瘤的根治性切除率，同时保护周围健康组织。为了获得图像，必须利用组织固有的特性产生光学对比度，或者需要将特殊的可视化标签附着到肿瘤上。在本篇综述中，回顾了荧光染料和探针的临床应用现状。
在本综述中，纳入了所有关于荧光成像的实验和临床研究。此外，为了寻找最佳的荧光成像方式，描述了荧光染料的所有特性。
尽管通过荧光进行成像的技术听起来很有前景，并且一些动物模型显示出了疗效，但这些药物的正式批准用于进一步的临床评估仍在热切期待中。
