Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Integr Cancer Ther. 2009 Dec;8(4):329-36. doi: 10.1177/1534735409352029. Epub 2009 Nov 18.
Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.
昼夜节律紊乱与炎症有关，炎症是癌症的一个既定风险因素。Per3 时钟基因多态性也与昼夜节律紊乱和癌症风险增加有关。患者在接受结肠镜检查前完成了一份问卷并提供了一份血样（n = 70）。在疲劳（多维疲劳量表）、抑郁症状（贝克抑郁量表 II）或睡眠障碍（匹兹堡睡眠质量指数）评分较高和较低的患者之间，或在 Per3 时钟基因变体不同的患者之间，比较了调整后的平均血清细胞因子浓度（IL-6、TNF-α、γ-INF、IL-1ra、IL-1-β、VEGF）。睡眠质量差与 VEGF 升高有关，与疲劳相关的活动减少与 TNF-α浓度升高有关。与 4/4 基因型相比，具有 4/5 或 5/5 Per3 可变串联重复序列的参与者具有更高的 IL-6 浓度。将昼夜节律紊乱与癌症联系起来的生物学过程仍有待阐明。增加的炎症细胞因子分泌可能起作用。
