1 型糖尿病青少年患者在反复酮症酸中毒但无临床明显脑水肿时 N-乙酰天冬氨酸/肌酸比值进行性降低：提示存在永久性脑损伤。
Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury.
机构信息
Departments of Radiology, University of California, Davis School of Medicine and UC Davis Children's Hospital, Sacramento, USA.
出版信息
AJNR Am J Neuroradiol. 2010 Apr;31(4):780-1. doi: 10.3174/ajnr.A1829. Epub 2009 Nov 19.
Abstract
Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.
摘要
最近的数据表明，DKA 可能导致 1 型糖尿病儿童的认知障碍。我们在一名青少年经历和之后 2 次无明显脑水肿的 DKA 发作期间测量了 NAA/Cr 比值。DKA 期间 NAA/Cr 比值降低，恢复后改善。然而，第二次 DKA 发作后（1.76）的 NAA/Cr 值低于第一次（1.97）。这些发现为 DKA 可能导致神经元损伤的假说提供了支持。
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