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本文引用的文献

1
Diabetic ketoacidosis and memory dysfunction in children with type 1 diabetes.1 型糖尿病儿童的糖尿病酮症酸中毒与记忆功能障碍。
J Pediatr. 2010 Jan;156(1):109-14. doi: 10.1016/j.jpeds.2009.07.054.
2
Neuro-cognitive performance in children with type 1 diabetes--a meta-analysis.1型糖尿病患儿的神经认知表现——一项荟萃分析。
J Pediatr Psychol. 2009 Apr;34(3):271-82. doi: 10.1093/jpepsy/jsn074. Epub 2008 Jul 17.
3
Cognition and diabetes: a lifespan perspective.认知与糖尿病：全生命周期视角
Lancet Neurol. 2008 Feb;7(2):184-90. doi: 10.1016/S1474-4422(08)70021-8.
4
Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis.糖尿病酮症酸中毒患儿的脑质子磁共振波谱分析
AJNR Am J Neuroradiol. 2007 May;28(5):895-9.
5
N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.中枢神经系统中的N-乙酰天门冬氨酸：从神经诊断学走向神经生物学。
Prog Neurobiol. 2007 Feb;81(2):89-131. doi: 10.1016/j.pneurobio.2006.12.003. Epub 2007 Jan 5.
6
Mechanism of cerebral edema in children with diabetic ketoacidosis.糖尿病酮症酸中毒患儿脑水肿的机制
J Pediatr. 2004 Aug;145(2):164-71. doi: 10.1016/j.jpeds.2004.03.045.
7
Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings, and early identification.儿童糖尿病酮症酸中毒中的脑水肿：自然病程、影像学表现及早期识别
Diabetes Care. 2004 Jul;27(7):1541-6. doi: 10.2337/diacare.27.7.1541.
8
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.N-乙酰天门冬氨酸，一种细胞功能障碍和神经元丢失的标志物：其与急性脑损伤研究的相关性。
J Neurochem. 2001 Apr;77(2):408-15. doi: 10.1046/j.1471-4159.2001.00285.x.

1 型糖尿病青少年患者在反复酮症酸中毒但无临床明显脑水肿时 N-乙酰天冬氨酸/肌酸比值进行性降低：提示存在永久性脑损伤。

Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury.

机构信息

Departments of Radiology, University of California, Davis School of Medicine and UC Davis Children's Hospital, Sacramento, USA.

出版信息

AJNR Am J Neuroradiol. 2010 Apr;31(4):780-1. doi: 10.3174/ajnr.A1829. Epub 2009 Nov 19.

DOI:10.3174/ajnr.A1829
PMID:19926705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7964239/
Abstract

Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.

摘要

最近的数据表明，DKA 可能导致 1 型糖尿病儿童的认知障碍。我们在一名青少年经历和之后 2 次无明显脑水肿的 DKA 发作期间测量了 NAA/Cr 比值。DKA 期间 NAA/Cr 比值降低，恢复后改善。然而，第二次 DKA 发作后（1.76）的 NAA/Cr 值低于第一次（1.97）。这些发现为 DKA 可能导致神经元损伤的假说提供了支持。