应激诱导蛋白 p8 参与多种生理和病理过程。
Stress-inducible protein p8 is involved in several physiological and pathological processes.
机构信息
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
出版信息
J Biol Chem. 2010 Jan 15;285(3):1577-81. doi: 10.1074/jbc.R109.080887. Epub 2009 Nov 19.
Abstract
p8 (NUPR1 (nuclear protein-1), Com1 (candidate of metastasis-1)) is a protein related to the high mobility group of transcriptional regulators. It is a key player in the cellular stress response and is involved in metastasis. p8 was first identified as a gene induced in pancreatitis but has been since found overexpressed in several cancers and pathological conditions. Despite its small size and apparently simple structure, p8 functions in several biochemical and genetic pathways, and its expression is crucial for in vivo metastasis in mice, for cytokine induction of metalloproteases, and for stress-induced cardiomyocyte hypertrophy. Understanding p8 functions will provide new opportunities for developing more effective therapeutic approaches to cancer and cardiovascular diseases.
摘要
p8（核蛋白-1，Com1（转移候选物-1））是一种与转录调节因子的高迁移率族相关的蛋白质。它是细胞应激反应的关键参与者，并且参与转移。p8 最初被鉴定为在胰腺炎中诱导的基因，但此后在几种癌症和病理条件下发现过度表达。尽管其体积小且结构显然简单，但 p8 在几种生化和遗传途径中发挥作用，其表达对于体内转移至关重要，对于细胞因子诱导的金属蛋白酶以及应激诱导的心肌细胞肥大。了解 p8 的功能将为开发更有效的癌症和心血管疾病治疗方法提供新的机会。
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