Cylwik Bogdan, Chrostek Lech, Daniluk Marta, Supronowicz Zbigniew, Szmitkowski Maciej
Department of Biochemical Diagnostics, Medical University, Bialystok, Poland.
J Nutr Sci Vitaminol (Tokyo). 2009;55(5):439-41. doi: 10.3177/jnsv.55.439.
The aim of this study was to evaluate the relationship between folate and homocysteine levels in alcoholics taking into consideration the liver enzyme activity as sensitive markers of hepatocellular injury. Folate and homocysteine concentrations did not differ between alcoholics classified according to the liver enzyme activity. The association between folate and homocysteine levels exists in the alcoholics with normal liver enzyme activity and in the controls. Therefore, we concluded that before the liver hepatocellular injury due to alcohol abuse, the correlation between folate and homocysteine concentrations in alcoholics exists as in the healthy controls. In the presence of hepatocellular injury, the association disappears.
本研究的目的是，将肝酶活性作为肝细胞损伤的敏感标志物，评估酗酒者体内叶酸和同型半胱氨酸水平之间的关系。根据肝酶活性分类的酗酒者中，叶酸和同型半胱氨酸浓度并无差异。叶酸和同型半胱氨酸水平之间的关联存在于肝酶活性正常的酗酒者以及对照组中。因此，我们得出结论，在因酒精滥用导致肝细胞损伤之前，酗酒者体内叶酸和同型半胱氨酸浓度之间的相关性与健康对照组相同。在存在肝细胞损伤的情况下，这种关联消失。
