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[1例腹膜后性腺外生殖细胞肿瘤完全缓解7年后发生的异时性睾丸肿瘤]

[A case of metachronous testicular tumor developing seven years after complete remission of retroperitoneal extragonadal germ cell tumor].

作者信息

Kawamura Norihiko, Yamamoto Keisuke, Yoshioka Iwao, Kiuchi Hiroshi, Momohara Sanehiro, Matsuoka Yasuhiro, Ichimaru Naotsugu, Nonomura Norio, Okuyama Akihiko, Kinoshita Tatsuya

机构信息

The Department of Urology, Osaka University Graduate School of Medicine.

出版信息

Hinyokika Kiyo. 2009 Oct;55(10):635-8.

PMID:19926951
Abstract

A 26-year-old man was admitted to our hospital with a chief complaint of left cervical lymphadenopathy. He was diagnosed as having seminoma by needle biopsy. Computed tomography revealed an aorto-caval retroperitoneal tumor. Levels of lactic deydrogenase, human beta-chorionic gonadotropin, alpha-fetoprotein were not elevated. No abnormal findings were present on palpation and ultrasonography of the testes. The patient was diagnosed as having a retroperitoneal extragonadal germ cell tumor (EGCT). Three courses of chemotherapy (bleomycin, etoposide and cisplatin) and another course of chemotherapy (etoposide, ifosfamide and cisplatin) were performed. Complete remission was achieved. Seven years later, the patient noticed an enlargement of his right scrotal contents. Neither distant metastasis nor lymph node metastasis was detected by computed tomography. Right radical orchiectomy was performed and histology revealed seminoma with yolk sac tumor components. No recurrence has been seen after 10 months.

摘要

一名26岁男性因左颈部淋巴结肿大为主诉入院。经针吸活检诊断为精原细胞瘤。计算机断层扫描显示腹主动脉 - 腔静脉后腹膜肿瘤。乳酸脱氢酶、人绒毛膜促性腺激素、甲胎蛋白水平未升高。睾丸触诊和超声检查未发现异常。该患者被诊断为腹膜后性腺外生殖细胞肿瘤(EGCT)。进行了三个疗程的化疗(博来霉素、依托泊苷和顺铂)以及另一个疗程的化疗(依托泊苷、异环磷酰胺和顺铂)。实现了完全缓解。七年后,患者注意到右侧阴囊内容物增大。计算机断层扫描未检测到远处转移和淋巴结转移。进行了右侧根治性睾丸切除术,组织学检查显示为伴有卵黄囊瘤成分的精原细胞瘤。10个月后未见复发。

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引用本文的文献

1
Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report.原发性性腺外生殖细胞肿瘤二十年后出现睾丸晚期复发并伴有罕见转移:一例报告
J Med Case Rep. 2021 Feb 5;15(1):59. doi: 10.1186/s13256-021-02667-y.
2
Playing the long surveillance ball game: Metachronous testicular tumor developing after treatment and remission of extragonadal germ cell tumor.进行长期监测:性腺外生殖细胞肿瘤治疗缓解后发生的异时性睾丸肿瘤。
Rare Tumors. 2019 Sep 9;11:2036361319873196. doi: 10.1177/2036361319873196. eCollection 2019.