向大卫·克莱恩博士致敬：一种解决外周神经老问题的新方法——对断裂轴突进行拼接而非再生。
A tribute to Dr. David Kline: a new approach to an old peripheral nerve problem--splicing instead of regenerating disrupted axons.
机构信息
Departments of Ophthalmology and Physiology, Neuroscience Program and Bioengineering Program, University of California, San Francisco, San Francisco, California, USA.
出版信息
Neurosurgery. 2009 Oct;65(4 Suppl):A52-4. doi: 10.1227/01.NEU.0000335655.66073.27.
OBJECTIVE
Our goal is to develop a novel method to repair damaged axons. This method relies on acutely restoring axonal continuity rather than the traditional approach of promoting axonal regeneration.
METHODS
Micro- and nanoechnological methods, in combination with focal application of electrical fields, are applied to individual and groups of axons both in vitro and in vivo.
RESULTS
Application of these techniques has permitted micromanipulation of axons at the cellular level and fusion of axonal membranes.
CONCLUSION
Although a great deal more work is necessary, our findings suggest that it may one day be possible to repair acutely disrupted axons by splicing their membranes back together.
目的
我们的目标是开发一种修复受损轴突的新方法。该方法依赖于急性恢复轴突连续性，而不是传统的促进轴突再生的方法。
方法
微纳技术方法与局部电场应用相结合，用于体外和体内的单个和多个轴突。
结果
应用这些技术可实现细胞水平的轴突微操作和轴突膜融合。
结论
尽管还需要做大量的工作，但我们的研究结果表明，将来有可能通过将其膜重新拼接在一起来修复急性中断的轴突。
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