Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA.
Neurosurgery. 2009 Oct;65(4 Suppl):A87-92. doi: 10.1227/01.NEU.0000335653.52938.F2.
In this review, we describe how therapies that promote axonal regeneration and neuronal protection can complement surgery for a successful functional restoration in peripheral nerve disorders. We discuss the advantages of peripheral drug delivery and the role of the neurosurgeon in the precise delivery of molecular therapies to surgically inaccessible structures. Strategies for enhancing uptake and retrograde transport of therapeutics, including gene therapy, are emphasized as conduits for delivery of therapeutics. Finally, candidate therapeutic proteins and genes are discussed in the context of application to degenerative disorders of the nervous system, including nerve injury, peripheral neuropathy, and amyotrophic lateral sclerosis.
在这篇综述中，我们描述了促进轴突再生和神经元保护的治疗方法如何与手术相结合，以成功恢复外周神经疾病的功能。我们讨论了外周药物输送的优势，以及神经外科医生在将分子治疗精确递送到手术不可及结构中的作用。强调了增强治疗药物摄取和逆行转运的策略，包括基因治疗，作为递药的途径。最后，讨论了候选治疗性蛋白质和基因在应用于神经系统退行性疾病（包括神经损伤、周围神经病和肌萎缩侧索硬化症）方面的情况。
