Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Obesity (Silver Spring). 2010 Aug;18(8):1638-45. doi: 10.1038/oby.2009.407. Epub 2009 Nov 19.
The burden of cardiovascular risk associated with obesity disproportionately affects African Americans and little is known about ethnic/racial differences in the relationship of obesity to cardiometabolic risk. This report assesses whether obesity is similarly associated with cardiometabolic risk factors in African Americans and whites of European ancestry. Cross-sectional observational data from the Jackson Heart Study (JHS) and the Framingham Heart Study (FHS) were compared. This analysis uses participants aged 35-74 years with BMI >18.5 kg/m(2), and free of prevalent cardiovascular disease (CVD), from the initial JHS clinical examination (2000-2004) and the FHS Offspring (1998-2001) and Third Generation (2002-2005) cohorts. Participants were evaluated for the presence of lipid abnormalities, hypertension, and diabetes. Overall, 4,030 JHS (mean age 54 years, 64% women) and 5,245 FHS (mean age 51 years, 54% women) participants were available for analysis. The prevalence of all risk factors except high triglycerides and low high-density lipoprotein (HDL) was substantially higher in JHS (all P < 0.001) and BMI was associated with increasing prevalence of most CVD risk factors within each race. For diabetes mellitus, hypertension, and low HDL, steeper relationships to BMI were observed in FHS than in JHS (P values <0.001-0.016). There were larger proportional increases in risk factor prevalence with increasing BMI in whites than in African Americans. The higher prevalence rates of cardiometabolic risk factors at nearly all levels of BMI in African Americans, however, suggest that additional factors contribute to the burden of CVD risk in African Americans.
与肥胖相关的心血管风险负担不成比例地影响非裔美国人，而关于肥胖与心脏代谢风险之间的种族差异知之甚少。本报告评估肥胖是否与非裔美国人和欧洲裔白种人心脏代谢风险因素具有相似的相关性。对比了来自 Jackson 心脏研究（JHS）和 Framingham 心脏研究（FHS）的横断面观察性数据。本分析使用了 JHS 初始临床检查（2000-2004 年）和 FHS 后代（1998-2001 年）和第三代（2002-2005 年）队列中年龄在 35-74 岁、BMI＞18.5kg/m²且无心血管疾病（CVD）病史的参与者数据。参与者评估了血脂异常、高血压和糖尿病的情况。总体而言，4030 名 JHS（平均年龄 54 岁，64%为女性）和 5245 名 FHS（平均年龄 51 岁，54%为女性）参与者可用于分析。除了高甘油三酯和低高密度脂蛋白（HDL）外，JHS 参与者所有风险因素的患病率均显著较高（均 P＜0.001），并且 BMI 与每个种族的大多数 CVD 风险因素的患病率呈正相关。对于糖尿病、高血压和低 HDL，FHS 中 BMI 与这些疾病的相关性要强于 JHS（P 值＜0.001-0.016）。随着 BMI 的增加，白人的危险因素患病率呈更大比例增加，而非裔美国人则不然。然而，非裔美国人在几乎所有 BMI 水平上的心脏代谢风险因素的更高患病率表明，其他因素也促成了非裔美国人 CVD 风险的负担。
