Jackson Heart Study, University of Mississippi Medical Center, Jackson State University, Jackson, MS, USA.
Obesity (Silver Spring). 2014 Mar;22(3):811-8. doi: 10.1002/oby.20307. Epub 2014 Feb 11.
To examine the relative association of abdominal visceral adipose tissue (VAT) with cardiometabolic risk factors between African and European Americans.
A cross-sectional study of 2,035 African Americans from the Jackson Heart Study (JHS) and 3,170 European Americans from the Framingham Heart Study (FHS) who underwent computed tomography assessment of VAT and subcutaneous adipose tissue (SAT) was conducted. The FHS participants were weighted to match the age distribution of the JHS participants, and the metabolic risk factors were examined by study groups in relation to VAT.
JHS participants had higher rates of obesity, hypertension, diabetes, and metabolic syndrome than FHS participants (all P = 0.001). The associations were weaker in JHS women for VAT with blood pressure, triglycerides, HDL-C, and total cholesterol (Pinteraction = 0.03-0.001) than FHS women. In contrast, JHS men had stronger associations for VAT with high triglycerides, low HDL, and metabolic syndrome (all Pinteraction = 0.001) compared to FHS men. Similar associations and gender patterns existed for SAT with most metabolic risk factors.
The relative association between VAT and cardiometabolic risk factors is weaker in JHS women compared to FHS women, whereas stronger associations with triglycerides and HDL were observed in JHS men.
研究非裔美国人和欧洲裔美国人之间腹部内脏脂肪组织（VAT）与心血管代谢危险因素的相对关联。
对接受 VAT 和皮下脂肪组织（SAT）计算机断层扫描评估的 2035 名非裔美国人和 3170 名欧洲裔美国人进行了横断面研究，这些参与者来自杰克逊心脏研究（JHS）和弗雷明汉心脏研究（FHS）。FHS 参与者的权重与 JHS 参与者的年龄分布相匹配，并根据研究组检查了代谢危险因素与 VAT 的关系。
JHS 参与者的肥胖、高血压、糖尿病和代谢综合征发生率高于 FHS 参与者（均 P = 0.001）。与 FHS 女性相比，JHS 女性的 VAT 与血压、甘油三酯、HDL-C 和总胆固醇的关联较弱（P 交互作用= 0.03-0.001）。相比之下，与 FHS 男性相比，JHS 男性的 VAT 与高甘油三酯、低 HDL 和代谢综合征的关联更强（均 P 交互作用= 0.001）。SAT 与大多数代谢危险因素也存在类似的关联和性别模式。
与 FHS 女性相比，JHS 女性中 VAT 与心血管代谢危险因素的相对关联较弱，而 JHS 男性中与甘油三酯和 HDL 的关联更强。
