Don Manuel, Elberling Claus, Maloff Erin
Electrophysiology Department, House Ear Institute, 2100 West Third Street, Fifth Floor, Los Angeles, CA 90057, USA.
J Am Acad Audiol. 2009 Feb;20(2):99-108. doi: 10.3766/jaaa.20.2.3.
The Stacked ABR (auditory brainstem response) attempts at the output of the auditory periphery to compensate for the temporal dispersion of neural activation caused by the cochlear traveling wave in response to click stimulation. Compensation can also be made at the input by using a chirp stimulus. It has been demonstrated that the Stacked ABR is sensitive to small tumors that are often missed by standard ABR latency measures.
Because a chirp stimulus requires only a single data acquisition run whereas the Stacked ABR requires six, we try to evaluate some indirect evidence justifying the use of a chirp for small tumor detection.
We compared the sensitivity and specificity of different Stacked ABRs formed by aligning the derived-band ABRs according to (1) the individual's peak latencies, (2) the group mean latencies, and (3) the modeled latencies used to develop a chirp.
For tumor detection with a chosen sensitivity of 95%, a relatively high specificity of 85% may be achieved with a chirp.
It appears worthwhile to explore the actual use of a chirp because significantly shorter test and analysis times might be possible.
叠加听性脑干反应（ABR）试图在听觉外周输出端对点击刺激时由耳蜗行波引起的神经激活的时间弥散进行补偿。也可以通过使用啁啾刺激在输入端进行补偿。已经证明，叠加ABR对标准ABR潜伏期测量常常遗漏的小肿瘤敏感。
由于啁啾刺激仅需要单次数据采集，而叠加ABR需要六次，我们试图评估一些间接证据，以证明使用啁啾进行小肿瘤检测的合理性。
我们比较了通过根据以下方式对齐导出频段ABR形成的不同叠加ABR的敏感性和特异性：（1）个体的峰值潜伏期，（2）组平均潜伏期，以及（3）用于开发啁啾的建模潜伏期。
对于选定敏感性为95%的肿瘤检测，使用啁啾可能实现相对较高的特异性，即85%。
探索啁啾的实际应用似乎是值得的，因为可能显著缩短测试和分析时间。
