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依托昔醇对外科手术性内毒素血症的心脏保护及脂质调节作用

[Cardioprotective and lipid-regulating effects of etoxidol with respect to surgical endotoxinemia].

作者信息

Vlasov A P, Nachkina E A, Grigor'eva T I, Leshchankina N Iu, Vlasova V P

出版信息

Eksp Klin Farmakol. 2009 Sep-Oct;72(5):46-9.

Abstract

Chronic experiments on stray dogs with modeling peritonitis showed that a complex therapy involving etoxidol favors improvement of the electrophysiological and metabolic heart activity and provides correction of the lipid distress syndrome. It is established that the lipid regulating effect of etoxidol is related not only to a decrease in the intensity of lipid peroxidation (LPO), but also to the A2-phospholipasae activity of this drug.

摘要

对患有腹膜炎模型的流浪狗进行的慢性实验表明,包含依托度酸的综合疗法有助于改善心脏的电生理和代谢活动,并纠正脂质代谢紊乱综合征。已确定依托度酸的脂质调节作用不仅与脂质过氧化(LPO)强度的降低有关,还与该药物的A2 - 磷脂酶活性有关。

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