Vlasov A P, Grigor'eva T I, Leshchankina N Iu, Nachkina E I, Timoshin D S
Eksp Klin Farmakol. 2010 Jun;73(6):10-3.
Chronic experiments on dogs showed that antioxidant drugs (reamberin, ximedone, vitamin E) are highly effective in correcting the functional and metabolic disorders in myocardium under endogenous intoxication conditions. Recovery of the functional activity was accompanied by correction of the lipid metabolism of cardiac cell structures. One mechanism of the drug action is related to a decrease in the lipid peroxidation rate and phospholipase A2 activity in cardiac tissue structures.
对狗的慢性实验表明，抗氧化药物（雷姆贝林、希美酮、维生素E）在内源性中毒条件下对纠正心肌功能和代谢紊乱非常有效。功能活性的恢复伴随着心脏细胞结构脂质代谢的纠正。药物作用的一种机制与心脏组织结构中脂质过氧化速率和磷脂酶A2活性的降低有关。
