TRPV1 受体拮抗剂的合成。
Synthesis of a TRPV1 receptor antagonist.
机构信息
Abbott Laboratories, GPRD Process Research and Development, Dept. R450, Bldg. R8, 1401 Sheridan Road, North Chicago, Illinois 60064, USA.
出版信息
J Org Chem. 2009 Dec 18;74(24):9539-42. doi: 10.1021/jo901943s.
PMID:19928811
Abstract
A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1.
摘要
本文描述了 TRPV1 受体拮抗剂 1 的五步合成路线。关键步骤涉及新颖的钯催化 4-氯-1-甲基吲唑 8 与苄基脲 9 的酰胺化反应，形成不对称取代的脲 1。
Zotero 插件