通过钯催化的 C-N 交叉偶联反应合成不对称二芳基脲。
Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2011 Jun 17;13(12):3262-5. doi: 10.1021/ol201210t. Epub 2011 May 23.
Abstract
A facile synthesis of unsymmetrical N,N'-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.
摘要
描述了一种简便的不对称 N,N'-二芳基脲的合成方法。通过利用 Pd 催化的脲的芳基化反应，可以从苄基脲通过一锅芳基化-脱保护反应，随后再进行第二次芳基化反应，以良好至优秀的收率合成一系列二芳基脲。
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