[氯丙嗪对A型产气荚膜梭菌毒素影响下大脑皮质电活动变化的作用]

[Effect of aminazin on changes in the electrical activity of the cerebral cortex under the influence of the toxin C1. perfringens type A].

作者信息

Tselukh A V, Makul'kin R F, Shandra A A

出版信息

Biull Eksp Biol Med. 1977 Oct;84(10):412-6.

Abstract

Experiments on cats revealed that injection of chlorpromazine (3 mg/kg of body weight, intramuscular) one hour prior to the Cl. perfingens toxin type A injection prevented the appearance of desynchronization of the electrical activity of the cerebral cortex usually observed during the first phase of intoxication. Chlorpromazine injection postpones the appearance of the electrical activity depression phase during the second phase and prolonged the animals' life span from 1.5 to 2 times. The effect of chlorpromazine was apparently connected with the block of the adrenergic structures of the brain stem reticular formation.

摘要

对猫的实验表明，在注射A型产气荚膜梭菌毒素前一小时注射氯丙嗪（3毫克/千克体重，肌肉注射），可防止通常在中毒第一阶段观察到的大脑皮层电活动去同步化现象的出现。注射氯丙嗪可推迟第二阶段电活动抑制期的出现，并使动物寿命延长1.5至2倍。氯丙嗪的作用显然与脑干网状结构肾上腺素能结构的阻断有关。

相似文献

1

[Effect of aminazin on changes in the electrical activity of the cerebral cortex under the influence of the toxin C1. perfringens type A].[氯丙嗪对A型产气荚膜梭菌毒素影响下大脑皮质电活动变化的作用]

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2

[Changes in the electric activity of the cerebral cortex in poisoning caused by Cl. perfringens toxin type A].[A型产气荚膜梭菌毒素中毒时大脑皮层电活动的变化]

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