Department of Pediatrics, Oslo University Hospital, Ullevaal, Norway.
Scand J Clin Lab Invest. 2009;69(8):858-64. doi: 10.3109/00365510903348677.
Adipokines have been implicated in the pathogenesis of metabolic syndrome (MetS) and insulin resistance. We investigated the association between these conditions and serum levels of visfatin, adiponectin and leptin.
175 overweight and obese boys and girls aged 3-17 years. MetS was defined as presence of at least three of the following: triglycerides >or= 1.24 mmol/L, high-density lipoprotein cholesterol <or= 1.03 mmol/L, fasting glucose >or= 6.1 mmol/L, elevated waist circumference and systolic or diastolic blood pressure >or= 90th percentile.
After adjustment for age and gender visfatin levels were significantly higher (median 19.0 [25th, 75th percentiles 11.9 , 37.1] vs. 15.2 [11.6 , 21.1] ng/ml; p(adjusted) = 0.02) in subjects with MetS (n = 41) compared to subjects without (n = 134). There were no significant differences in adiponectin or leptin levels between the two groups after adjustment for age and gender. Visfatin levels increased proportionally with number of MetS components (beta = 0.16, 95%CI 0.04, 0.28; p(adjusted) = 0.01), and adiponectin levels decreased proportionally with number of components (beta = -0.11, 95%CI -0.18, -0.04; p(adjusted) = 0.002). Leptin levels were not related to number of components of MetS. Unlike visfatin, both adiponectin (beta = -0.24, 95%CI -0.33, -0.15; p adjusted < 0.001) and leptin (beta = 0.14, 95%CI 0.01, 0.28; p adjusted = 0.03) were associated with insulin resistance.
The elevation of visfatin observed in children and adolescents with MetS was proportionate to number of components of MetS but was not associated with insulin resistance. The increase in visfatin may contribute to low-grade systemic inflammation associated with MetS.
脂肪因子参与了代谢综合征（MetS）和胰岛素抵抗的发病机制。我们研究了这些条件与血清内脂素、脂联素和瘦素水平之间的关系。
175 名超重和肥胖的 3-17 岁男孩和女孩。MetS 的定义为至少有以下三种情况存在：甘油三酯 >或= 1.24mmol/L，高密度脂蛋白胆固醇 <或= 1.03mmol/L，空腹血糖 >或= 6.1mmol/L，腰围增大以及收缩压或舒张压 >或= 90 百分位数。
在调整年龄和性别后，患有 MetS（n=41）的受试者血清内脂素水平明显高于无 MetS（n=134）的受试者（中位数 19.0[25 分位，75 分位 11.9, 37.1]vs.15.2[11.6, 21.1]ng/ml；调整后 p 值=0.02）。在调整年龄和性别后，两组间脂联素或瘦素水平无显著差异。内脂素水平与 MetS 成分数量成比例增加（β=0.16，95%CI0.04，0.28；调整后 p 值=0.01），而脂联素水平与成分数量成比例降低（β=-0.11，95%CI-0.18，-0.04；调整后 p 值=0.002）。瘦素水平与 MetS 的成分数量无关。与内脂素不同，脂联素（β=-0.24，95%CI-0.33，-0.15；调整后 p 值<0.001）和瘦素（β=0.14，95%CI0.01，0.28；调整后 p 值=0.03）与胰岛素抵抗均相关。
在患有 MetS 的儿童和青少年中观察到的内脂素升高与 MetS 的成分数量成比例，但与胰岛素抵抗无关。内脂素的增加可能导致与 MetS 相关的低度全身炎症。
