Samsam-Shariat Seyyed Ziaedin, Bolhasani Mohammad, Sarrafzadegan Nizal, Najafi Somayeh, Asgary Sedigheh
Isfahan Pharmaceutical Sciences Research Center AND School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atheroscler. 2014 Jul;10(4):218-26.
The observed relationships between visfatin, peroxidases activity, and metabolic syndrome (MetS) are inconsistent; therefore, this study was undertaken to understand these relationships.
This cross-sectional study was conducted as a part of the Isfahan Healthy Heart Program, Iran. A blood sample of 90 MetS and non-MetS patients were used to estimate total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs), fasting blood glucose (FBG), waist circumference (WC), systolic blood pressure (SBP) and diastolic blood pressure (DBP), visfatin and peroxidases activity. Data analysis for MetS group was carried out in two ways. (1) MetS with three components and with > 3 components. (2) MetS with hyperglycemia and without hyperglycemia.
SBP, DBP, WC, FBG, TC, TG, LDL-C, and were higher and HDL-C levels was lower in MetS patients. There was a significant correlation between visfatin levels and peroxidases activity in MetS patients with three components. Levels of visfatin were significantly higher in male as compared to female subjects in the MetS with three components group. There was a significant decrease in peroxidases activity in > 45 years old subjects in the MetS with > 3 components group. A significant correlation was observed between serum visfatin levels and FBG in the MetS without hyperglycemia group.
Peroxidases activities in MetS patients can be related to visfatin levels. Gender influences on peroxidases activity probably and was lower in female patients with MetS. Hyperglycemia does not influence peroxidases activities and visfatin levels.
已观察到内脂素、过氧化物酶活性与代谢综合征（MetS）之间的关系并不一致；因此，开展本研究以了解这些关系。
本横断面研究作为伊朗伊斯法罕健康心脏项目的一部分进行。采集90例代谢综合征患者和非代谢综合征患者的血样，以评估总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TGs）、空腹血糖（FBG）、腰围（WC）、收缩压（SBP）和舒张压（DBP）、内脂素和过氧化物酶活性。对代谢综合征组的数据进行了两种方式的分析。（1）具有三个组分和超过三个组分的代谢综合征。（2）伴有高血糖和不伴有高血糖的代谢综合征。
代谢综合征患者的收缩压、舒张压、腰围、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇较高，而高密度脂蛋白胆固醇水平较低。在具有三个组分的代谢综合征患者中，内脂素水平与过氧化物酶活性之间存在显著相关性。在具有三个组分的代谢综合征组中，男性的内脂素水平显著高于女性。在具有超过三个组分的代谢综合征组中，45岁以上受试者的过氧化物酶活性显著降低。在不伴有高血糖的代谢综合征组中，观察到血清内脂素水平与空腹血糖之间存在显著相关性。
代谢综合征患者的过氧化物酶活性可能与内脂素水平有关。性别可能对内过氧化物酶活性有影响，且在患有代谢综合征的女性患者中较低。高血糖不影响过氧化物酶活性和内脂素水平。
