胎儿生长受限时应用近红外光谱评估胎盘功能。
Evaluation of placental function using near infrared spectroscopy during fetal growth restriction.
机构信息
Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
出版信息
J Perinat Med. 2010;38(1):29-32. doi: 10.1515/jpm.2010.003.
OBJECTIVES
To investigate whether a near infrared spectroscopy (NIRS) system is useful for evaluation of the placental function in cases of fetal growth restriction (FGR).
METHODS
Subjects included 282 delivered neonates of appropriate for gestational age (AGA) and 44 small for gestational age (SGA) babies. The measurement of the concentration of oxyhemoglobin (HbO(2)) and deoxyhemoglobin (HHb) was conducted using transabdominal NIRS targeting the placenta at around 20 weeks, 30 weeks and after 36 weeks of gestation and calculated tissue oxygen indexes (TOI=HbO(2)/total Hb). We correlated between TOIs and causes of FGR.
RESULTS
TOIs measured immediately before delivery in the SGA group with severe pre-eclampsia (79.2+/-3.8 (%+/-standard deviation (SD); P=0.002)) and placental abnormalities (78.2+/-3.6; P=0.043) were higher than in the AGA group (74.0+/-4.5). TOIs in the SGA group with umbilical cord abnormalities were lower (69.7+/-7.7; P=0.024) than in the AGA group.
CONCLUSION
NIRS might provide information about blood oxygen level of the intervillous space and thus explain the cause of FGR.
目的
研究近红外光谱（NIRS）系统是否可用于评估胎儿生长受限（FGR）的胎盘功能。
方法
研究对象包括 282 例胎龄适当的足月新生儿（AGA）和 44 例小于胎龄儿（SGA）。在妊娠 20 周、30 周和 36 周左右通过经腹 NIRS 对胎盘进行了氧合血红蛋白（HbO(2))和脱氧血红蛋白（HHb)浓度的测量，并计算了组织氧指数（TOI=HbO(2)/总 Hb）。我们将 TOI 与 FGR 的原因进行了相关性分析。
结果
严重子痫前期（79.2+/-3.8（%+/-标准差（SD）；P=0.002））和胎盘异常（78.2+/-3.6；P=0.043）的 SGA 组在分娩前立即测量的 TOI 高于 AGA 组（74.0+/-4.5）。脐带异常的 SGA 组的 TOI 较低（69.7+/-7.7；P=0.024）。
结论
NIRS 可能提供胎盘绒毛间隙血氧水平的信息，从而解释 FGR 的原因。
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