Computational Genetics Laboratory and Department of Genetics, Dartmouth Medical School, Lebanon, NH, USA.
Expert Rev Proteomics. 2009 Dec;6(6):647-59. doi: 10.1586/epr.09.86.
Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly available to the scientific community. As our knowledge of protein-protein interactions increases, it is important to give thought to the different ways that these resources can impact biomedical research. In this article, we highlight the importance of protein-protein interactions in human genetics and genetic epidemiology. Since protein-protein interactions demonstrate one of the strongest functional relationships between genes, combining genomic data with available proteomic data may provide us with a more in-depth understanding of common human diseases. In this review, we will discuss some of the fundamentals of protein interactions, the databases that are publicly available and how information from these databases can be used to facilitate genome-wide genetic studies.
蛋白质组学和蛋白质-蛋白质相互作用的研究在我们从系统层面理解人类疾病的努力中变得越来越重要。由于蛋白质相互作用数据库的开发和整理，这些相互作用网络的最新信息可供科学界获取和公开使用。随着我们对蛋白质-蛋白质相互作用的了解不断增加，我们必须考虑这些资源可能会以不同的方式影响生物医学研究。在本文中，我们强调了蛋白质-蛋白质相互作用在人类遗传学和遗传流行病学中的重要性。由于蛋白质-蛋白质相互作用显示了基因之间最强的功能关系之一，因此将基因组数据与可用的蛋白质组数据相结合，可能会让我们更深入地了解常见的人类疾病。在这篇综述中，我们将讨论一些蛋白质相互作用的基本原理、可公开获取的数据库以及如何使用这些数据库来促进全基因组遗传研究。
