European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.
Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Methods Mol Biol. 2022;2449:27-42. doi: 10.1007/978-1-0716-2095-3_2.
Molecular interaction databases aim to systematically capture and organize the experimental interaction information described in the scientific literature. These data can then be used to perform network analysis, to assign putative roles to uncharacterized proteins and to investigate their involvement in cellular pathways.This chapter gives a brief overview of publicly available molecular interaction databases and focuses on the members of the IMEx Consortium, on their curation policies and standard data formats. All of the goals achieved by IMEx databases over the last 15 years, the data types provided and the many different ways in which such data can be utilized by the research community, are described in detail. The IMEx databases curate molecular interaction data to the highest caliber, following a detailed curation model and supplying rich metadata by employing common curation rules and harmonized standards. The IMEx Consortium provides comprehensively annotated molecular interaction data integrated into a single, non-redundant, open access dataset.
分子相互作用数据库旨在系统地捕获和组织科学文献中描述的实验相互作用信息。然后，这些数据可用于进行网络分析，为未鉴定的蛋白质赋予假定的作用，并研究它们在细胞途径中的参与情况。本章简要概述了公开可用的分子相互作用数据库，并重点介绍了 IMEx 联盟的成员、它们的策展政策和标准数据格式。详细描述了 IMEx 数据库在过去 15 年中实现的所有目标、提供的数据类型以及研究界可以利用这些数据的多种不同方式。IMEx 数据库按照详细的策展模型进行分子相互作用数据的策展，并通过使用通用策展规则和协调标准提供丰富的元数据。IMEx 联盟提供全面注释的分子相互作用数据，集成到一个单一的、非冗余的、开放访问的数据集。
