Department of Medicinal Chemistry, ShanDong University, Ji'nan, ShanDong, P.R. China.
Mini Rev Med Chem. 2009 Oct;9(11):1329-41. doi: 10.2174/138955709789878097.
Chloramphenicol (CAP) is a widely used broad-spectrum antibiotic. As the precursor of CAP, chloramphenicol bases are stereochemically pure agents and could be used as resolution agents, chiral catalysts and so on. This review summarizes these applications and discusses the structural modifications of chloramphenicol bases.
氯霉素(CAP)是一种广泛使用的广谱抗生素。作为 CAP 的前体,氯霉素碱是立体化学纯的试剂,可用于作为拆分试剂、手性催化剂等。本文综述了这些应用,并讨论了氯霉素碱的结构修饰。