肿瘤微环境诱导的自噬在癌症不同细胞及阶段中的作用
The role of autophagy induced by tumor microenvironment in different cells and stages of cancer.
作者信息
Yang Xue, Yu Dan-Dan, Yan Fei, Jing Ying-Ying, Han Zhi-Peng, Sun Kai, Liang Lei, Hou Jing, Wei Li-Xin
机构信息
Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, 225 Changhai Road, 200438 Shanghai, China.
Central laboratory, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
出版信息
Cell Biosci. 2015 Mar 28;5:14. doi: 10.1186/s13578-015-0005-2. eCollection 2015.
Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in controlling tumor fate and autophagy induced by the tumor microenvironment is attracting more and more attention. Autophagy can be induced by several stressors in the tumor microenvironment and autophagy modifies the tumor microenvironment, too. Autophagy has dual roles in tumor growth. In this review, we discussed the interaction between autophagy and the tumor microenvironment and the paradoxical roles of autophagy on tumor growth at different stages of tumor development.
肿瘤的发生是一个非常复杂的过程，恶性肿瘤的侵袭和转移是其标志，也是难以攻克的难题。肿瘤微环境在控制肿瘤命运方面发挥着重要作用，由肿瘤微环境诱导的自噬正吸引着越来越多的关注。自噬可由肿瘤微环境中的多种应激源诱导，并且自噬也会改变肿瘤微环境。自噬在肿瘤生长中具有双重作用。在本综述中，我们讨论了自噬与肿瘤微环境之间的相互作用，以及自噬在肿瘤发展不同阶段对肿瘤生长的矛盾作用。
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