Department of Periodontology, Universidad Complutense de Madrid, Madrid, Spain.
J Clin Periodontol. 2009 Dec;36(12):1059-66. doi: 10.1111/j.1600-051X.2009.01489.x.
To describe histologically the early phases of soft tissue healing to implants placed into fresh extraction sockets.
In 16 beagle dogs, 64 3.25-mm-wide cylindrical screw implants were inserted into the distal sockets of the third and fourth lower premolars using a one-stage trans-mucosal healing protocol. Biopsies were then taken at 1, 2, 4 and 8 weeks and prepared for histological examination.
One-week specimens showed a junctional epithelium and an underlying loose connective tissue rich in inflammatory cells. At 2 weeks, signs of epithelial proliferation and a more organized connective tissue were observed. At 4 and 8 weeks, inflammation was absent; the epithelium appeared mature and in close contact with the surface of the healing abutment or the implant. The connective tissue was dense in an area close to the implant surface and the fibres were aligned parallel to the implant surface. The soft tissue dimensions at 8 weeks were approximately 5 mm, including about 3-3.5 mm of epithelium and 1-1.5 mm of connective tissue.
Soft tissue healing to implants placed in fresh extraction sockets may result in a longer epithelial interface than implants placed in a healed ridge.
描述即刻植入新鲜拔牙窝后软组织愈合的早期阶段。
在 16 只比格犬中，使用一期经黏膜愈合方案将 64 个 3.25mm 宽的圆柱形螺钉植入第三和第四下前磨牙的远中拔牙窝中。然后在 1、2、4 和 8 周时取活检并准备进行组织学检查。
1 周标本显示结合上皮和富含炎症细胞的疏松结缔组织。在 2 周时，观察到上皮增殖和更有组织的结缔组织的迹象。在 4 和 8 周时，炎症消失；上皮成熟，与愈合基台或种植体表面紧密接触。在靠近种植体表面的区域，结缔组织致密，纤维与种植体表面平行排列。8 周时软组织的尺寸约为 5mm，包括约 3-3.5mm 的上皮和 1-1.5mm 的结缔组织。
与植入愈合牙槽嵴的种植体相比，植入新鲜拔牙窝的种植体可能会导致更长的上皮界面。
