白细胞介素-1诱导人滑膜细胞中中性粒细胞激活蛋白（白细胞介素-8）和单核细胞趋化肽的基因表达。
Interleukin-1 induced gene expression of neutrophil activating protein (interleukin-8) and monocyte chemotactic peptide in human synovial cells.
作者信息
DeMarco D, Kunkel S L, Strieter R M, Basha M, Zurier R B
机构信息
Department of Medicine, University of Pennsylvania, Philadelphia.
出版信息
Biochem Biophys Res Commun. 1991 Jan 31;174(2):411-6. doi: 10.1016/0006-291x(91)91431-b.
We report here that human synovial cells stimulated by interleukin-1 alpha and interleukin-1 beta express mRNA for both IL-8 (neutrophil chemotactic peptide) and monocyte chemotactic protein. IL-1 stimulated synovial cells from both osteoarthritis and rheumatoid arthritis patients exhibited similar mRNA expression of interleukin-8 and monocyte chemotactic protein. A capacity to produce factors selectively chemotactic for neutrophils, lymphocytes and monocytes provides a mechanism whereby synovial cells can facilitate inflammatory arthritis.
我们在此报告，白细胞介素-1α和白细胞介素-1β刺激的人滑膜细胞表达白细胞介素-8（中性粒细胞趋化肽）和单核细胞趋化蛋白的信使核糖核酸。白细胞介素-1刺激的骨关节炎和类风湿关节炎患者的滑膜细胞表现出白细胞介素-8和单核细胞趋化蛋白相似的信使核糖核酸表达。产生对中性粒细胞、淋巴细胞和单核细胞具有选择性趋化作用的因子的能力提供了一种机制，借此滑膜细胞可促进炎性关节炎。
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