利用云计算搜索 SNP。
Searching for SNPs with cloud computing.
机构信息
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
出版信息
Genome Biol. 2009;10(11):R134. doi: 10.1186/gb-2009-10-11-r134. Epub 2009 Nov 20.
As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from http://bowtie-bio.sourceforge.net/crossbow/.
随着 DNA 测序技术的发展速度超过了计算机速度的提升，我们急需加速对齐和 SNP 呼叫等任务。Crossbow 是一个云计算软件工具，它结合了 aligner Bowtie 和 SNP 调用者 SOAPsnp。使用 Hadoop 并行执行，Crossbow 使用从云计算服务租用的 320 个 CPU 集群在三小时内分析了人类基因组 38 倍覆盖的数据，费用约为 85 美元。Crossbow 可从 http://bowtie-bio.sourceforge.net/crossbow/ 获取。
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