Davies-Husband C R, Montgomery P, Premachandra D, Hellquist H
ENT department, Norfolk and Norwich University Hospital, Norwich, UK.
J Laryngol Otol. 2010 Feb;124(2):226-9. doi: 10.1017/S0022215109991228. Epub 2009 Nov 25.
We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid.
Case report and review of the literature concerning laryngeal composite tumours.
Primary laryngeal carcinoma is the most common malignancy of the upper aerodigestive tract. The vast majority are of the squamous cell type. Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date. In each case, the neuroendocrine component has been small cell carcinoma.
The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour. Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.
我们报告首例由鳞状细胞癌合并非典型类癌组成的喉复合性肿瘤病例。
病例报告及有关喉复合性肿瘤的文献复习。
原发性喉癌是上呼吸消化道最常见的恶性肿瘤。绝大多数为鳞状细胞型。原发性神经内分泌肿瘤是喉恶性肿瘤中罕见的异质性亚型，包括典型类癌、非典型类癌、小细胞癌和副神经节瘤。原发性喉神经内分泌癌与鳞状细胞癌合并更为罕见，迄今为止关于这种所谓复合性肿瘤仅有14篇文献报道。在每例病例中，神经内分泌成分均为小细胞癌。
包含不止一种组织学类型的原发性肿瘤的治疗需根据生物学行为最具侵袭性的肿瘤来制定。准确诊断喉复合性肿瘤的组织学性质对于确保最佳治疗至关重要。
